Title:
DEVICE AND METHOD FOR PREDICTING PATHOLOGICAL-IMAGE-BASED NUCLEIC ACID AMOUNT AND PROPOSING OPTIMAL GENE TEST
Document Type and Number:
WIPO Patent Application WO/2024/019326
Kind Code:
A1
Abstract:
The present disclosure relates to a method and a device for predicting a nucleic acid amount on the basis of a pathological image and proposing the optimal gene test. This method may comprise the steps of: receiving a pathological image of a slide; extracting, from the pathological image, information about the amount of nucleic acid that can be extracted from a predetermined paraffin section; determining the quality grade of the nucleic acid on the basis of the pathological image; labeling at least one of a plurality of tests as a success or a failure on the basis of the information about the extractable nucleic acid amount and/or the quality grade; and selecting the optimal test from among the plurality of tests on the basis of the labeling information about each of the plurality of tests.
Inventors:
KIM TAE JUNG (KR)
Application Number:
PCT/KR2023/007903
Publication Date:
January 25, 2024
Filing Date:
June 09, 2023
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
G16B40/20; C12Q1/6809; C12Q1/6841; C12Q1/6851; C12Q1/6869; G06N3/08; G16B20/00
Domestic Patent References:
| WO2022147503A1 | 2022-07-07 | |||
| WO2018065434A1 | 2018-04-12 |
Other References:
HE CHANGLONG; WEI CHENGCHENG; WEN JUN; CHEN SHI; CHEN LING; WU YUE; SHEN YIFAN; BAI HUILI; ZHANG YANGLI; CHEN XUEPING; LI XIAOSONG: "Comprehensive analysis of NGS and ARMS-PCR for detecting EGFR mutations based on 4467 cases of NSCLC patients", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER INTERNATIONAL, BERLIN., DE, vol. 148, no. 2, 24 October 2021 (2021-10-24), DE , pages 321 - 330, XP037679137, ISSN: 0171-5216, DOI: 10.1007/s00432-021-03818-w
OSINSKI BOLESŁAW L., BENTAIEB AÏCHA, HO IRVIN, JONES RYAN D., JOSHI ROHAN P., WESTLEY ANDREW, CARLSON MICHAEL, WILLIS CALEB, SCHLE: "Artificial intelligence-augmented histopathologic review using image analysis to optimize DNA yield from formalin-fixed paraffin-embedded slides", MODERN PATHOLOGY, NATURE PUBLISHING GROUP, GB, vol. 35, no. 12, 1 December 2022 (2022-12-01), GB , pages 1791 - 1803, XP093131687, ISSN: 0893-3952, DOI: 10.1038/s41379-022-01161-0
SHAKER NADA, SARDANA RUHANI, HAMASAKI SATOSHI, NOHLE DAVID G., AYERS LEONA W., PARWANI ANIL V.: "Accuracy of whole slide image based image analysis is adversely affected by preanalytical factors such as stained tissue slide and paraffin block age", JOURNAL OF PATHOLOGY INFORMATICS, MEDKNOW PUBLICATIONS AND MEDIA PVT. LTD., IN, vol. 13, 1 January 2022 (2022-01-01), IN , pages 100121, XP093131690, ISSN: 2153-3539, DOI: 10.1016/j.jpi.2022.100121
OSINSKI BOLESŁAW L., BENTAIEB AÏCHA, HO IRVIN, JONES RYAN D., JOSHI ROHAN P., WESTLEY ANDREW, CARLSON MICHAEL, WILLIS CALEB, SCHLE: "Artificial intelligence-augmented histopathologic review using image analysis to optimize DNA yield from formalin-fixed paraffin-embedded slides", MODERN PATHOLOGY, NATURE PUBLISHING GROUP, GB, vol. 35, no. 12, 1 December 2022 (2022-12-01), GB , pages 1791 - 1803, XP093131687, ISSN: 0893-3952, DOI: 10.1038/s41379-022-01161-0
SHAKER NADA, SARDANA RUHANI, HAMASAKI SATOSHI, NOHLE DAVID G., AYERS LEONA W., PARWANI ANIL V.: "Accuracy of whole slide image based image analysis is adversely affected by preanalytical factors such as stained tissue slide and paraffin block age", JOURNAL OF PATHOLOGY INFORMATICS, MEDKNOW PUBLICATIONS AND MEDIA PVT. LTD., IN, vol. 13, 1 January 2022 (2022-01-01), IN , pages 100121, XP093131690, ISSN: 2153-3539, DOI: 10.1016/j.jpi.2022.100121
Attorney, Agent or Firm:
BLT PATENT & LAW FIRM (KR)
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