Title:
DEVICES AND METHODS FOR MANAGEMENT OF BONE DENSITY
Document Type and Number:
WIPO Patent Application WO2002062352
Kind Code:
A3
Abstract:
The invention features devices and methods for the delivery of a formulation to an individual to stabilize or increase bone mass by increasing bone deposition and/or decreasing bone resorption. In the present invention, a drug formulation comprising a bisphosphonate is provided parenterally in a sustained release dosage from, e.g., as an injected matrix or stored within a drug delivery device. In a specific embodiment, the dosage form may be implanted or injected into a site in the body (i.e., implantation site) and a conduit, e.g., a catheter, can be used to transport the formulation from the dosage form for release at a site in the body distal form the implantation site.
Inventors:
CHAN TAI WAH (US)
Application Number:
PCT/US2002/003794
Publication Date:
April 03, 2003
Filing Date:
February 07, 2002
Export Citation:
Assignee:
DURECT CORP (US)
CHAN TAI WAH (US)
CHAN TAI WAH (US)
International Classes:
A61K9/22; A61L26/00; A61L27/18; A61L27/54; A61P19/10; (IPC1-7): A61K9/00; A61K31/663; A61P19/10
Domestic Patent References:
| WO2000064516A1 | 2000-11-02 | |||
| WO2001085217A1 | 2001-11-15 |
Foreign References:
| EP0449405A2 | 1991-10-02 |
Other References:
OSTERMAN T ET AL: "Slow-release clodronate in prevention of inflammation and bone loss associated with adjuvant arthritis.", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 280, no. 2, 1997, pages 1001 - 1007, XP002223035, ISSN: 0022-3565
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