Title:
DEVICES AND METHODS TO IMMOBILIZE ANALYTES OF INTEREST
Document Type and Number:
WIPO Patent Application WO2005114145
Kind Code:
A3
Abstract:
The invention provides devices and methods using assemblies of shaped inserts coated with diverse binder materials optionally positioned inside conformal housings. The devices are capable of immobilizing target analytes of interest (e.g., specific or groups of biomolecules) and are optionally usable as single units, linear strips or array formats. The coatings on the inserts and, optionally also on the inside walls of the housings, create variable gaps with narrow fluid paths resulting in enhanced diffusion and absorption of target analytes from transiting fluid samples while exhibiting minimal resistance to flow or back pressure commonly seen in conventional plug-type packings. The devices are intended for sample preparations requiring: filtering, enriching, separating, purifying of target analytes by selective absorption/elution as part of desalting, buffer exchange and/or enrichment applications in analyses by mass spectrometry and/or electrophoresis; purifying biomolecules; culturing cells; analytical separation processes, and general chemical, biological and/or biochemical separations in manual or automated systems.
Inventors:
SOSTEK RONALD (US)
PERIANA CECILY (US)
DAVIS MARK (US)
PERIANA CECILY (US)
DAVIS MARK (US)
Application Number:
PCT/US2005/016743
Publication Date:
September 08, 2006
Filing Date:
May 12, 2005
Export Citation:
Assignee:
HARVARD APPARATUS INC (US)
SOSTEK RONALD (US)
PERIANA CECILY (US)
DAVIS MARK (US)
SOSTEK RONALD (US)
PERIANA CECILY (US)
DAVIS MARK (US)
International Classes:
G01N30/00; G01N1/34; G01N21/00
Foreign References:
| US4147752A | 1979-04-03 | |||
| US5171537A | 1992-12-15 | |||
| US5888834A | 1999-03-30 | |||
| US3700609A | 1972-10-24 |
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