DEXMEDETOMIDINE TRANSDERMAL COMPOSITION, TRANSDERMAL PATCH, AND METHOD FOR PREPARING TRANSDERMAL PATCH AND USE THEREOF

WIPO Patent Application WO/2024/037545

A1

A dexmedetomidine transdermal composition, a transdermal patch, and a method for preparing the transdermal patch and use thereof. The composition comprises dexmedetomidine or a pharmaceutically acceptable salt thereof, propylene glycol, a pressure-sensitive adhesive, and a stabilizer. The propylene glycol serves as a solubilizer of the transdermal composition. After transdermal administration, the concentration of dexmedetomidine in the plasma starts to increase remarkably 8 hours after administration, the blood concentration reaches the maximum and is always maintained at a relatively stable level within 24-72 hours after administration, and meanwhile, in the in vitro transdermal process of the composition, drug release amount in unit time can reach the maximum at 8 hours after administration. Moreover, the stabilizer and the pressure-sensitive adhesive jointly form a skeleton structure, which allows for remarkably improved adhesion performance and better fitting experience of a patient; meanwhile, the product has good stability and is free of skin irritation, and thereby the safety is greatly improved when being applied to the human body.

LIU PENG (CN)
LI KE (CN)
LIU CAN (CN)
WU YOUBIN (CN)
DENG CHUNYA (CN)
LIU RONG (CN)
LV JINLIANG (CN)
LI LIE (CN)

PCT/CN2023/113167

February 22, 2024

August 15, 2023

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YICHANG HUMANWELL PHARMACEUTICAL CO LTD (CN)

A61K9/70; A61K31/4174; A61P29/00

CN110585173A	2019-12-20
CN110022865A	2019-07-16
CN110604728A	2019-12-24
TW201609200A	2016-03-16
CN102753169A	2012-10-24
CN107929268A	2018-04-20

AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)

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