Title:
DI-ARYL SUBSTITUTED PYRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5
Document Type and Number:
WIPO Patent Application WO2004089303
Kind Code:
A3
Abstract:
Novel pyrazole compounds such as compounds of the formula (I): (where A, A<1>, A<2>, B, R<11>, W, X, Y and Z are as defined herein) in which the pyrazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, obesity, drug addiction, drug abuse, drug withdrawal and other diseases.
Inventors:
COSFORD NICHOLAS D P (US)
EASTMAN BRIAN W (US)
HUANG DEHUA (US)
SMITH NICHOLAS D (US)
TEHRANI LIDA R (US)
ESSA HU (US)
EASTMAN BRIAN W (US)
HUANG DEHUA (US)
SMITH NICHOLAS D (US)
TEHRANI LIDA R (US)
ESSA HU (US)
Application Number:
PCT/US2004/011651
Publication Date:
April 28, 2005
Filing Date:
March 30, 2004
Export Citation:
Assignee:
MERCK & CO INC (US)
COSFORD NICHOLAS D P (US)
EASTMAN BRIAN W (US)
HUANG DEHUA (US)
SMITH NICHOLAS D (US)
TEHRANI LIDA R (US)
ESSA HU (US)
COSFORD NICHOLAS D P (US)
EASTMAN BRIAN W (US)
HUANG DEHUA (US)
SMITH NICHOLAS D (US)
TEHRANI LIDA R (US)
ESSA HU (US)
International Classes:
C07D401/04; A61K; (IPC1-7): C07D401/04
Foreign References:
| US6069157A | 2000-05-30 |
Download PDF:
Previous Patent: POSH POLYPEPTIDES, COMPLEXES AND RELATED METHODS
Next Patent: ANTIANDROGENS WITH MARGINAL AGONIST ACTIVITY AND METHODS OF USE
Next Patent: ANTIANDROGENS WITH MARGINAL AGONIST ACTIVITY AND METHODS OF USE