Title:
DIACYGLYCEROL MIMETICS AND METHODS OF USING THE SAME AS PROTEIN KINASE C ALPHA ACTIVATORS AND APOPTOSIS INDUCERS
Document Type and Number:
WIPO Patent Application WO/2003/013504
Kind Code:
A1
Abstract:
Disclosed herein are methods for inducing apoptosis by exposing cells to an apoptic inducing amount of one or more of newly created DAG-lactone mimetics. In one embodiment of the new class of DAG compounds the new DAG-mimetic compound satisfies general formula (I) as follows:, wherein R¿1?, R¿2?, R¿3?, and R¿4? are independently selected from the group consisting essentially of hydrogen, oxygen, nitrogen, hydroxyls, halogens, branched or unbranched, substituted or unsubstituted, aliphatic groups, heteroatom (e.g., O, S, N, hydroxyls, halogens) substituted aliphatic groups, aromatic groups, and all major functional groups. Preferably, R¿1? is O and R¿3? is a hydroxyalkyl such as CH¿2?OH. Also preferably, R¿2? is an alkylidene group derived from an aldehyde and R¿4? is an alkyl group derived from an acid chloride. The size of the lactone ring may be varied by either increasing or decreasing the ring size. Preferably, R¿1?, R¿2?, R¿3?, and R¿4? when comprising carbon chains or rings, comprise groups of carbon chains or rings of 12 carbon atoms or less.
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Inventors:
MARQUEZ VICTOR (US)
LEE JEEWOO (KR)
BLUMBERG PETER M (US)
KAZANIETZ MARCELO G (US)
LEE JEEWOO (KR)
BLUMBERG PETER M (US)
KAZANIETZ MARCELO G (US)
Application Number:
PCT/US2002/025088
Publication Date:
February 20, 2003
Filing Date:
August 06, 2002
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
UNIV PENNSYLVANIA (US)
MARQUEZ VICTOR (US)
LEE JEEWOO (KR)
BLUMBERG PETER M (US)
KAZANIETZ MARCELO G (US)
UNIV PENNSYLVANIA (US)
MARQUEZ VICTOR (US)
LEE JEEWOO (KR)
BLUMBERG PETER M (US)
KAZANIETZ MARCELO G (US)
International Classes:
A61K31/34; (IPC1-7): A61K31/34
Foreign References:
| US6294573B1 | 2001-09-25 |
Attorney, Agent or Firm:
Caldwell, Lisa M. (OR, US)
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