Title:
DIAGNOSIS REAGENT FOR PHYLLODES TUMOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/050860
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medical biology, and particularly, to use of RUNX2 as a marker in preparing a diagnosis or detection reagent for a malignant phyllodes tumor. The detection reagent can assist in, according to the expression level of the RUNX2 in phyllodes tumors of different grades, conventional tissue biopsy, and can perform diagnosis, differential diagnosis, grading, and prognostic analysis on the phyllodes tumors. An RUNX2 detection primer sequence and a detection antibody are important components of a diagnosis or detection reagent or kit, which allows the detection of the malignant phyllodes tumor to be simpler, faster, and more accurate, exhibits very good clinical application value, and helps to further improve the diagnosis level for the malignant phyllodes tumor. The diagnosis and detection kit is expected to become the first diagnosis and detection kit for the malignant phyllodes tumor.
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Inventors:
NIE YAN (CN)
SONG ERWEI (CN)
LEI RONG (CN)
HUANG HONGYAN (CN)
HE SHISHI (CN)
AILIFEIRE YILIHAMU (CN)
SONG ERWEI (CN)
LEI RONG (CN)
HUANG HONGYAN (CN)
HE SHISHI (CN)
AILIFEIRE YILIHAMU (CN)
Application Number:
PCT/CN2022/118894
Publication Date:
March 14, 2024
Filing Date:
September 15, 2022
Export Citation:
Assignee:
SUN YAT SEN MEMORIAL HOSPITAL OF SUN YAT SEN UNIV (CN)
International Classes:
C07K14/705; C12Q1/6886; G01N33/574
Domestic Patent References:
| WO2022111390A1 | 2022-06-02 |
Foreign References:
| CN113929764A | 2022-01-14 | |||
| CN114113607A | 2022-03-01 | |||
| US20220025465A1 | 2022-01-27 | |||
| US20090232819A1 | 2009-09-17 | |||
| US20130316359A1 | 2013-11-28 |
Other References:
YANG ZHENGJUN; ZHANG BIN; LIU BOWEN; XIE YEGONG; CAO XUCHEN: "Combined Runx2 and Snail overexpression is associated with a poor prognosis in breast cancer", TUMOR BIOLOGY, KARGER, BASEL, CH, vol. 36, no. 6, 22 January 2015 (2015-01-22), CH , pages 4565 - 4573, XP035527553, ISSN: 1010-4283, DOI: 10.1007/s13277-015-3101-3
ZHOU BINGJUAN, HUANG LI-JUAN; CAO JIAN-JIANG: "Expression of Runx2 and Slug in Breast Cancer and Its Significance", JOURNAL OF CHINESE ONCOLOGY, vol. 23, no. 7, 20 July 2017 (2017-07-20), pages 619 - 622, XP093146575, ISSN: 1671-170X, DOI: 10.11735/j.issn.1671-170X.2017.07.B012
ZHOU BINGJUAN, HUANG LI-JUAN; CAO JIAN-JIANG: "Expression of Runx2 and Slug in Breast Cancer and Its Significance", JOURNAL OF CHINESE ONCOLOGY, vol. 23, no. 7, 20 July 2017 (2017-07-20), pages 619 - 622, XP093146575, ISSN: 1671-170X, DOI: 10.11735/j.issn.1671-170X.2017.07.B012
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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