Title:
DIAGNOSIS AND TREATMENT OF VASCULAR DISEASE
Document Type and Number:
WIPO Patent Application WO2003007801
Kind Code:
A3
Abstract:
The present invention is based at least in part on the discovery of polymorphisms within the phospholipase C gamma 1 (PLCG1) gene and the plasminogen activator inhibitor type 2 (PAI-2) gene. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of a PLCG1 or PAI-2 gene. The invention also provides methods for identifying specific alleles of polymorphic regions of a PLCG1 or PAI-2 gene, methods for determining whether a subject is or is not at risk of developing a disease which is associated with a specific allele of a polymorphic region of a PLCG1 or PAI-2 gene, e.g., a vascular disease, based on detection of polymorphisms within the PLCG1 or PAI-2 gene, and kits for performing such methods. The invention further provides methods for classifying a subject who is or is not at risk for developing, a vascular disease or disorder as a candidate for a particular clinical course of therapy or a particular diagnostic evaluation. The invention further provides methods for selecting a clinical course of therapy or a diagnostic evaluation to treat a subject who is or not at risk for developing, a vascular disease or disorder.
Inventors:
MCCARTHY JEANETTE (US)
Application Number:
PCT/US2002/023041
Publication Date:
September 23, 2004
Filing Date:
July 19, 2002
Export Citation:
Assignee:
VITIVITY INC (US)
MCCARTHY JEANETTE (US)
MCCARTHY JEANETTE (US)
International Classes:
C12Q1/68; (IPC1-7): C12Q1/68; C07H21/04; C12P19/34
Foreign References:
| US5474796A | 1995-12-12 |
Download PDF: