Title:
DIAGNOSTIC AGENT FOR PANCREATIC FUNCTION
Document Type and Number:
WIPO Patent Application WO/2022/014605
Kind Code:
A1
Abstract:
The present invention relates to a method for diagnosing pancreatic function, the method comprising the steps of: administering a diagnostic agent for pancreatic function to a subject, the agent containing a compound represented by general formula (1-0) as an active ingredient; detecting the compound (1-0) accumulated in the pancreas; and quantitatively analyzing the amount of the compound (1-0) accumulated in the pancreas. [In general formula (1-0), R represents -O (CH2) n-, -O (CH2) nOC2H4-, -CH2O (CH2) n-, or -CH2O (CH2) nOC2H4-, n represents an integer of 1-5, and Q1 represents F or -OCH3.]
Inventors:
OHBA HIROYUKI (JP)
TSUKADA HIDEO (JP)
TSUKADA HIDEO (JP)
Application Number:
PCT/JP2021/026345
Publication Date:
January 20, 2022
Filing Date:
July 13, 2021
Export Citation:
Assignee:
HAMAMATSU PHOTONICS KK (JP)
International Classes:
A61K51/04; A61K31/501; C07D401/12; A61K101/00; A61K101/02
Domestic Patent References:
| WO2014030709A1 | 2014-02-27 | |||
| WO2014030709A1 | 2014-02-27 | |||
| WO2005115971A1 | 2005-12-08 |
Foreign References:
| JP2017206457A | 2017-11-24 |
Other References:
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JOURNAL OF ABDOMINAL EMERGENCY MEDICINE, vol. 28, 2008, pages 561 - 571
JOURNAL OF THE PANCREAS, vol. 10, 2009, pages 280 - 283
PLOS ONE, vol. 14, 2019, pages e0213202
J. LABELED COMP. RADIOPHARM., vol. 56, no. 11, 2013, pages 553 - 561
FEBS J, vol. 280, 2013, pages 1039 - 1050
ENDOCR REV, vol. 29, 2008, pages 351 - 366
KIDNEY INT, vol. 70, 2006, pages 1560 - 1566
WU JINZI, LUO XIAOTING, THANGTHAENG NOPPORN, SUMIEN NATHALIE, CHEN ZHENGLAN, RUTLEDGE MARGARET A., JING SIQUN, FORSTER MICHAEL J.,: "Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes", BIOCHEMISTRY AND BIOPHYSICS REPORTS, ELSEVIER, vol. 11, 1 September 2017 (2017-09-01), pages 119 - 129, XP055898750, ISSN: 2405-5808, DOI: 10.1016/j.bbrep.2017.07.007
KIM MIN JOO, CHOI OK KYONG, CHAE KYUNG SIL, KIM JUNG HEE, KOMATSU MASAAKI, TANAKA KEIJI, LEE HAKMO, CHUNG SUNG SOO, KWAK SOO HEON,: "Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse β-Cells", ENDOCRINOLOGY AND METABOLISM, vol. 30, no. 1, 1 January 2015 (2015-01-01), pages 65 - 70, XP055898747, ISSN: 2093-596X, DOI: 10.3803/EnM.2015.30.1.65
KIM-MULLER JA YOUNG, FAN JASON, KIM YOUNG JUNG R., LEE SEUNG-AH, ISHIDA EMI, BLANER WILLIAM S., ACCILI DOMENICO: "Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice", NATURE COMMUNICATIONS, vol. 7, no. 1, 1 November 2016 (2016-11-01), XP055898744, DOI: 10.1038/ncomms12631
MA ZUHENG; MORUZZI NOAH; CATRINA SERGIU-BOGDAN; GRILL VALDEMAR; BJÖRKLUND ANNELI : "Hyperoxia inhibits glucose-induced insulin secretion and mitochondrial metabolism in rat pancreatic islets", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 443, no. 1, 2 December 2013 (2013-12-02), Amsterdam NL , pages 223 - 228, XP028805835, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2013.11.088
JOURNAL OF ABDOMINAL EMERGENCY MEDICINE, vol. 28, 2008, pages 561 - 571
JOURNAL OF THE PANCREAS, vol. 10, 2009, pages 280 - 283
PLOS ONE, vol. 14, 2019, pages e0213202
J. LABELED COMP. RADIOPHARM., vol. 56, no. 11, 2013, pages 553 - 561
FEBS J, vol. 280, 2013, pages 1039 - 1050
ENDOCR REV, vol. 29, 2008, pages 351 - 366
KIDNEY INT, vol. 70, 2006, pages 1560 - 1566
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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