Title:
DIAGNOSTIC METHOD FOR EARLY PERIODONTITIS USING S100 PROTEIN IN BODILY FLUID, METHOD FOR PROVIDING INFORMATION, COMPOSITION, AND KIT
Document Type and Number:
WIPO Patent Application WO/2020/040609
Kind Code:
A1
Abstract:
The present invention relates to a diagnostic method for periodontitis, and a method of providing information for diagnosis of periodontitis, the diagnostic method comprising the steps of: sampling a bodily fluid isolated from a subject; analyzing S100A8 and S100A9 protein expression levels in the bodily fluid; and associating the subject with periodontitis if the S100A8 protein expression level in the bodily fluid is higher than an S100A8 protein expression level in a bodily fluid of a normal control group, and the S100A9 protein expression level in the bodily fluid is lower than an S100A9 protein expression level in the bodily fluid of the normal control group. Furthermore, the present invention may provide a composition for diagnosis of periodontitis, comprising an agent measuring the S100A8 and S100A9 protein expression levels, and a kit for diagnosis of periodontitis, comprising the composition for diagnosis of periodontitis.
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Inventors:
KIM HYUN-DUCK (KR)
Application Number:
PCT/KR2019/010792
Publication Date:
February 27, 2020
Filing Date:
August 23, 2019
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
G01N33/68
Domestic Patent References:
| WO2013162100A1 | 2013-10-31 |
Foreign References:
| KR20150052311A | 2015-05-13 | |||
| JP2016031306A | 2016-03-07 |
Other References:
RAMSEIER, C. A.: "Identification of pathogen and host-response markers correlated with periodontal disease", JOURNAL OF PERIODONTOLOGY, 2009, pages 436 - 446, XP055400653, DOI: 10.1902/jop.2009.080480
TAYLOR, J. J.: "Protein biomarkers of periodontitis in saliva", ISRN INFLAMMATION, vol. 2014, 22 April 2014 (2014-04-22), pages 1 - 18, XP055131500
KARNA, S.: "Salivary S100 proteins screen periodontitis among Korean adults", JOURNAL OF CLINICAL PERIODONTOLOGY, 27 December 2018 (2018-12-27), pages 181 - 188, XP055689035
SHIN, M.-S.: "Deep sequencing salivary proteins for periodontitis using proteomics", CLINICAL ORAL INVESTIGATIONS, 15 December 2018 (2018-12-15), pages 3571 - 3580, XP036860417, DOI: 10.1007/s00784-018-2779-1
TAYLOR, J. J.: "Protein biomarkers of periodontitis in saliva", ISRN INFLAMMATION, vol. 2014, 22 April 2014 (2014-04-22), pages 1 - 18, XP055131500
KARNA, S.: "Salivary S100 proteins screen periodontitis among Korean adults", JOURNAL OF CLINICAL PERIODONTOLOGY, 27 December 2018 (2018-12-27), pages 181 - 188, XP055689035
SHIN, M.-S.: "Deep sequencing salivary proteins for periodontitis using proteomics", CLINICAL ORAL INVESTIGATIONS, 15 December 2018 (2018-12-15), pages 3571 - 3580, XP036860417, DOI: 10.1007/s00784-018-2779-1
Attorney, Agent or Firm:
HANYANG PATENT FIRM (KR)
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