DIAGNOSTIC AND THERAPEUTIC ALKYL PIPERIDINE/PIPERAZINE COMPOUNDS AND PROCESS

WIPO Patent Application WO2004063150

A3

Piperidine or piperazine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The compounds are characterized by the formulae: (I), (II), (III), (IV), (V) wherein: n is an integer of 1 to 6; X, Y, Z1 and Z2 can be the same or different and are hydrogen, halo, haloalkyl, alkyl, aryl, (C1-C6)alkoxy, N-alkyl, (C2-C6)acyloxy, N-alkylene, -SH, -SR, wherein R is from the same group as R1 and R2 and can be the same or different than R1 and R2, amino, nitro, cyano, hydroxy, C(=O)OR6, -C(=O)NR5R4, NR3R2, or S(=O)kR1 wherein k is 1 0r 2, and R1 to R6 are independently hydrogen or (C1-C6)alkyl; R1 and R2 can be the same or different and are hydrogen, (C1-C6)alkyl, hydroxyalkyl or mercaptoalkyl, -C(=O)OR1, cyano, (C1-C6)alkenyl, (C2-C6) alkynyl, or 1, 2, 4-oxadiazol-5-yl optionally substituted at the 3-position by Z4 wherein any (C1-C6)alky, (C1-C6)alkanoyl, (C2-C6)alkenyl or (C2-C6)alkynyl can optionally be substituted by 1, 2 or 3 Z; R7 can be hydrogen, O or phenyl; R8 can be hydrogen, phenyl, halophenyl, nitrophenyl, pyridyl, piperonyl or sulfoxonitrophenyl; Z4 is (C1-C6)alkyl or phenyl, optionally substituted by 1, 2 or 3 Z1; W is O or S; T is amino or C1-C6aminoalkyl; A is N or C; T is C1-C6alkyl or sulfonyl and V is alkyl (C0-C6), alkenyl, alkynyl, haloaryl, alkyl phenol, alkyl halophenyl, and R1 or R2 as indicated above and D is phenyl, naphrhyl, thienyl or pyridinyl.

JP3852708	Amino alcohol derivative
WO/1982/004392	METHOD OF PREPARING PHARMACEUTICAL COMPOSITIONS CONTAINING ALPHA-/2-/BIS(1-METHYLETHYL)AMINO/ETHYL/ALPHA-PHENYL 2-PYRIDINE ACETAMIDE OR ONE OF ITS SALTS
JP5674723	Substituted 4-aminocyclohexane derivative

ELMALEH DAVID R
CHOI SANGWOON
FISHMAN ALAN J

PCT/US2003/041731

June 02, 2005

December 31, 2003

Click for automatic bibliography generation  

GEN HOSPITAL CORP (US)

A61K31/44; A61K31/445; A61K31/497; C07D211/26; C07D211/56; C07D211/58; C07D213/75; C07D241/04; C07D295/215; C07D401/00; C07D401/12; C07D; (IPC1-7): A61K31/497; A61K31/44; A61K31/445; C07D211/56; C07D241/04; C07D401/00

US5652240A	1997-07-29
US4476129A	1984-10-09
US6387389B1	2002-05-14

View/Download PDF      PDF Help

Previous Patent: INDENONCARBOXYLIC ACIDS DERIVATIVES AND THEIR USE FOR THE TREATMENT OF AND PREVENTING DIABETES AND D...

Next Patent: NOVEL TYROSINE KINASE INHIBITORS