Title:
DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PHOSPHODIESTERASE 1B (PDE1B)
Document Type and Number:
WIPO Patent Application WO2004080270
Kind Code:
A3
Abstract:
The invention provides a human PDE1B which is associated with the cardiovascular disorders, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of PDE1B as well as pharmaceutical compositions comprising such compounds.
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Inventors:
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
Application Number:
PCT/EP2004/002065
Publication Date:
December 23, 2004
Filing Date:
February 27, 2004
Export Citation:
Assignee:
BAYER HEALTHCARE AG (DE)
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
International Classes:
C12Q1/44; G01N33/574; G01N33/68; (IPC1-7): G01N33/68; G01N33/574; C12Q1/44
Domestic Patent References:
| WO2003020702A2 | 2003-03-13 |
Foreign References:
| EP1085092A1 | 2001-03-21 | |||
| US6372777B1 | 2002-04-16 | |||
| US5885834A | 1999-03-23 |
Other References:
KRUUSE CHRISTINA ET AL: "The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 420, no. 1, 18 May 2001 (2001-05-18), pages 55 - 65, XP002285171, ISSN: 0014-2999
JIANG XIN ET AL: "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, no. 20, 1996, pages 11236 - 11241, XP002285172, ISSN: 0027-8424
YU JOSEPHINE ET AL: "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1", CELLULAR SIGNALLING, vol. 9, no. 7, 1997, pages 519 - 529, XP002285173, ISSN: 0898-6568
RYBALKIN SERGEI D ET AL: "Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype", JOURNAL OF CLINICAL INVESTIGATION, vol. 100, no. 10, 15 November 1997 (1997-11-15), pages 2611 - 2621, XP002285174, ISSN: 0021-9738
KOSTIC M M ET AL: "Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, XX, XX, vol. 29, no. 11, November 1997 (1997-11-01), pages 3135 - 3146, XP002278927, ISSN: 0022-2828
JIANG XIN ET AL: "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, no. 20, 1996, pages 11236 - 11241, XP002285172, ISSN: 0027-8424
YU JOSEPHINE ET AL: "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1", CELLULAR SIGNALLING, vol. 9, no. 7, 1997, pages 519 - 529, XP002285173, ISSN: 0898-6568
RYBALKIN SERGEI D ET AL: "Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype", JOURNAL OF CLINICAL INVESTIGATION, vol. 100, no. 10, 15 November 1997 (1997-11-15), pages 2611 - 2621, XP002285174, ISSN: 0021-9738
KOSTIC M M ET AL: "Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, XX, XX, vol. 29, no. 11, November 1997 (1997-11-01), pages 3135 - 3146, XP002278927, ISSN: 0022-2828
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