Title:
DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH VITAMIN D (1,25-DIHYDROXYVITAMIN D3) RECEPTOR 1 (VDR1)
Document Type and Number:
WIPO Patent Application WO2005101022
Kind Code:
A3
Abstract:
The invention provides a human VDR1 which is associated with the infections, cardiovascular diseases, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton disorders and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections cardiovascular diseases, respiratory diseases, dermatological diseases, endocrinological deiseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton disorders and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of VDR1 as well as pharmaceutical compositions comprising such compounds.
Inventors:
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
Application Number:
PCT/EP2005/003471
Publication Date:
February 09, 2006
Filing Date:
April 02, 2005
Export Citation:
Assignee:
BAYER HEALTHCARE AG (DE)
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
International Classes:
G01N33/574; G01N33/82; (IPC1-7): G01N33/82; G01N33/574
Domestic Patent References:
| WO1998051678A1 | 1998-11-19 | |||
| WO2004020379A1 | 2004-03-11 | |||
| WO2003041657A2 | 2003-05-22 | |||
| WO1999049027A1 | 1999-09-30 |
Foreign References:
| US20030207810A1 | 2003-11-06 |
Other References:
VOGEL ARNDT ET AL: "Genetic association of vitamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune hepatitis", HEPATOLOGY, vol. 35, no. 1, 2002, pages 126 - 131, XP002345952
CSÁSZÁR A ET AL: "Receptor polymorphisms and diseases", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 414, no. 1, 2001, pages 9 - 22, XP002345953
CONSOLINI R ET AL: "Effects of vitamin D on the growth of normal and malignant B-cell progenitors", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 126, no. 2, November 2001 (2001-11-01), pages 214 - 219, XP002346061
MANFREDINI R ET AL: "Induction of a functional vitamin D receptor in all-trans-retinoic acid- induced monocytic differentiation of M2-type leukemic blast cells", CANCER RESEARCH, vol. 59, no. 15, 1 August 1999 (1999-08-01), pages 3803 - 3811, XP002346062
CSÁSZÁR A ET AL: "Receptor polymorphisms and diseases", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 414, no. 1, 2001, pages 9 - 22, XP002345953
CONSOLINI R ET AL: "Effects of vitamin D on the growth of normal and malignant B-cell progenitors", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 126, no. 2, November 2001 (2001-11-01), pages 214 - 219, XP002346061
MANFREDINI R ET AL: "Induction of a functional vitamin D receptor in all-trans-retinoic acid- induced monocytic differentiation of M2-type leukemic blast cells", CANCER RESEARCH, vol. 59, no. 15, 1 August 1999 (1999-08-01), pages 3803 - 3811, XP002346062
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