Title:
DIARYLAMIDE COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/253802
Kind Code:
A1
Abstract:
A use of a diarylamide compound having the structure as shown in formula (I) or a pharmaceutically acceptable salt thereof in preparing a drug which acts as a urea transporter protein inhibitor, and a novel diarylamide compound. The diarylamide compound has urea transporter protein inhibitor effect, and can produce urea selective diuresis in the body without obvious toxicity.
Inventors:
YANG BAOXUE (CN)
LI RUNTAO (CN)
LI MIN (CN)
ZHANG SHUN (CN)
ZHAO YAN (CN)
LI RUNTAO (CN)
LI MIN (CN)
ZHANG SHUN (CN)
ZHAO YAN (CN)
Application Number:
PCT/CN2020/096939
Publication Date:
December 24, 2020
Filing Date:
June 19, 2020
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
A61K31/167; A61K31/166; A61P7/10; A61P9/04; A61P9/12
Foreign References:
| JP2007126454A | 2007-05-24 | |||
| CN104825454A | 2015-08-12 | |||
| CN104602682A | 2015-05-06 | |||
| CN102757447A | 2012-10-31 |
Other References:
ROBERT J; ROBERT-PIESSARD S; COURANT J; LE BAUT G; ROBERT B; LANG F; PETIT J; GRIMAUD N; WELIN L: "Non-carboxylic antiinflammatory compounds.III.N-(4, 6-Dimethylpyridin-2-yl)arylcarboxamides and arylthiocarboxamides acting as brain edema inhibitors.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 12, 1 January 1995 (1995-01-01), pages 915 - 924, XP004040220, ISSN: 0223-5234, DOI: 10.1016/0223-5234(96)88310-3
MIN LI, WENG IEONG TOU, HONG ZHOU, FEI LI, HUIWEN REN, CALVIN YU-CHIAN CHEN , BAOXUE YANG: "Developing Hypothetical Inhibition Mechanism of Novel Urea Transporter B Inhibitor.", SCIENTIFIC REPORTS, vol. 4, no. 1, 5775, 22 July 2014 (2014-07-22), pages 1 - 12, XP055767191, ISSN: 2045-2322, DOI: 10.1038/srep05775
MENG YAN , ZHAO XUEJIAN ,YANG BAOXUE: "Research Progress of Urea Channel Protein", FOREIGN MEDICAL SCIENCES(SECTION OF PATHOPHYSIOLOGY AND CLINICAL MEDICINE), vol. 24, no. 4, 31 August 2004 (2004-08-31), pages 349 - 351, XP055767204, ISSN: 1001-1773
ZHAO; SONAWANE D; LEVIN N D; YANG M H; B: "Comparative transport efficiencies of urea analogues through urea transporter UT-B", BBA - BIOMEMBRANES ACTA, vol. 1768, no. 7, 1 July 2007 (2007-07-01), pages 1815 - 1821, XP022113273, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2007.04.010
YANG BBANKIR L: "Renal handling of urea in transgenic mice lacking the urea transporter UT-B", AM J PHYSIOL RENAL PHYSIOL, vol. 288, 2005, pages F881 - F896
SANDS JM: "Renal urea transporters", CURR OPIN NEPHROL HYPERTENS, vol. 13, 2004, pages 525 - 532
SMITH CPROUSSELET G: "Facilitative Urea transporters", J MEMBRANCBIOI, vol. 183, 2001, pages 1 - 14
BAGNASCO SM: "Gene structure of urea transporters", AM J PHYSIOL, vol. 284, 2003, pages F3 - F10
SHAYAKUL CHEDIGER MA: "The SLC14 gene family of urea transporters", PI/UEGERS, vol. 447, 2004, pages 603 - 609
YANG BBANKIR LGILLEPSIE A: "Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B", JBIOT CHEM, vol. 277, 2002, pages 10633 - 10637
BANKIR LCHEN KYANG B: "Renal handling of urea in transgenic mice lacking the urea transporter UT-B", AM J PHYSIOL, vol. 286, 2004, pages F144 - F151
FENTON RACHOU CLSTEWART GS: "Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct", PROC NATL ACAD SCI, vol. 101, 2004, pages 7469 - 7474
FENTON, R. A.FLYNN ASHODEINDE A: "Renal phenotype of UT-A urea transporter knockout mice", JAM SOC NEPHROL, vol. 16, 2005, pages 1583 - 1592
JIANG, T.LI, Y.LAYTON, A.T.WANG, W.SUN, Y.LI, M.ZHOU, H.YANG, B.: "Generation and phenotypic analysis of mice lacking all urea transporters", KIDNEY INT, vol. 91, 2017, pages 338 - 351
See also references of EP 3984534A4
MIN LI, WENG IEONG TOU, HONG ZHOU, FEI LI, HUIWEN REN, CALVIN YU-CHIAN CHEN , BAOXUE YANG: "Developing Hypothetical Inhibition Mechanism of Novel Urea Transporter B Inhibitor.", SCIENTIFIC REPORTS, vol. 4, no. 1, 5775, 22 July 2014 (2014-07-22), pages 1 - 12, XP055767191, ISSN: 2045-2322, DOI: 10.1038/srep05775
MENG YAN , ZHAO XUEJIAN ,YANG BAOXUE: "Research Progress of Urea Channel Protein", FOREIGN MEDICAL SCIENCES(SECTION OF PATHOPHYSIOLOGY AND CLINICAL MEDICINE), vol. 24, no. 4, 31 August 2004 (2004-08-31), pages 349 - 351, XP055767204, ISSN: 1001-1773
ZHAO; SONAWANE D; LEVIN N D; YANG M H; B: "Comparative transport efficiencies of urea analogues through urea transporter UT-B", BBA - BIOMEMBRANES ACTA, vol. 1768, no. 7, 1 July 2007 (2007-07-01), pages 1815 - 1821, XP022113273, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2007.04.010
YANG BBANKIR L: "Renal handling of urea in transgenic mice lacking the urea transporter UT-B", AM J PHYSIOL RENAL PHYSIOL, vol. 288, 2005, pages F881 - F896
SANDS JM: "Renal urea transporters", CURR OPIN NEPHROL HYPERTENS, vol. 13, 2004, pages 525 - 532
SMITH CPROUSSELET G: "Facilitative Urea transporters", J MEMBRANCBIOI, vol. 183, 2001, pages 1 - 14
BAGNASCO SM: "Gene structure of urea transporters", AM J PHYSIOL, vol. 284, 2003, pages F3 - F10
SHAYAKUL CHEDIGER MA: "The SLC14 gene family of urea transporters", PI/UEGERS, vol. 447, 2004, pages 603 - 609
YANG BBANKIR LGILLEPSIE A: "Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B", JBIOT CHEM, vol. 277, 2002, pages 10633 - 10637
BANKIR LCHEN KYANG B: "Renal handling of urea in transgenic mice lacking the urea transporter UT-B", AM J PHYSIOL, vol. 286, 2004, pages F144 - F151
FENTON RACHOU CLSTEWART GS: "Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct", PROC NATL ACAD SCI, vol. 101, 2004, pages 7469 - 7474
FENTON, R. A.FLYNN ASHODEINDE A: "Renal phenotype of UT-A urea transporter knockout mice", JAM SOC NEPHROL, vol. 16, 2005, pages 1583 - 1592
JIANG, T.LI, Y.LAYTON, A.T.WANG, W.SUN, Y.LI, M.ZHOU, H.YANG, B.: "Generation and phenotypic analysis of mice lacking all urea transporters", KIDNEY INT, vol. 91, 2017, pages 338 - 351
See also references of EP 3984534A4
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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