Title:
DIASTEREOMER PREPARATION METHOD, AND SOLID-PHASE PHOTOSENSITIZER
Document Type and Number:
WIPO Patent Application WO/2024/048438
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a diastereomer preparation method whereby it becomes possible to produce a desired diastereomer from a diastereomer mixture with high efficiency; and a solid-phase photosensitizer which is used in the diastereomer preparation method. The solution for the problem is a diastereomer preparation method in which one diastereomer among cis-trans isomers is selectively prepared utilizing recycle HPLC, the method comprising: a step A that is a separation step for introducing a cis-trans isomer mixture into the separation column to selectively collect one diastereomer; a step B that is a photoisomerization reaction step for irradiating a solution containing the other diastereomer which is obtained after the step A or C with light in the presence of a photosensitizer in a photoisomerization reactor to induce a photoisomerization reaction; and a step C that is a step for introducing a cis-trans isomer mixture produced in the step B into a separation column to selectively collect the one diastereomer.
Inventors:
TAKAHASHI HIDEYO (JP)
MAKINO KOSHO (JP)
SUGA MAYUKO (JP)
KANEMARU KUNIO (JP)
KURODA NORITAKA (JP)
MUTO EIGO (JP)
SHIROMA RYO (JP)
MAKINO KOSHO (JP)
SUGA MAYUKO (JP)
KANEMARU KUNIO (JP)
KURODA NORITAKA (JP)
MUTO EIGO (JP)
SHIROMA RYO (JP)
Application Number:
PCT/JP2023/030673
Publication Date:
March 07, 2024
Filing Date:
August 25, 2023
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUND (JP)
IWASAKI ELECTRIC CO LTD (JP)
YMC CO LTD (JP)
IWASAKI ELECTRIC CO LTD (JP)
YMC CO LTD (JP)
International Classes:
C07C231/24; C07C231/12; C07C233/11; C07C235/34; C07C259/06; C07D335/16; C09K3/00; B01D15/14
Domestic Patent References:
| WO2021039800A1 | 2021-03-04 |
Foreign References:
| JP2008509199A | 2008-03-27 | |||
| JP2020200265A | 2020-12-17 | |||
| JP2015229753A | 2015-12-21 | |||
| JP2015051930A | 2015-03-19 |
Other References:
MONI LISA, BANFI LUCA, BASSO ANDREA, MORI ALESSIA, RISSO FEDERICA, RIVA RENATA, LAMBRUSCHINI CHIARA: "A Thorough Study on the Photoisomerization of Ferulic Acid Derivatives", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH, DE, vol. 2021, no. 11, 19 March 2021 (2021-03-19), DE , pages 1737 - 1749, XP093064582, ISSN: 1434-193X, DOI: 10.1002/ejoc.202100064
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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