Title:
DIBENZYLBUTYROLACTONE GLYCOSIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/051666
Kind Code:
A1
Abstract:
Disclosed are a dibenzylbutyrolactone glycoside compound as shown in formula (I), a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the preparation of a drug for the prevention, treatment or adjuvant treatment of diseases associated with abnormal activity or expression levels of phosphodiesterase 4 (PDE4). The disclosed dibenzylbutyrolactone glycoside compound has a strong inhibitory activity against PDE4 and a strong anti-inflammatory activity, and can be used for the prevention, treatment or adjuvant treatment of diseases associated with abnormal activity and/or expression levels of PDE4. In addition, the disclosed method for preparing the dibenzylbutyrolactone glycoside compound can achieve the stereoselective preparation of the compound.
Inventors:
XU YECHUN (CN)
TANG WEI (CN)
CHEN GUOFENG (CN)
FENG CHUNLAN (CN)
LIU JIAYUAN (CN)
YANG TAO (CN)
TANG WEI (CN)
CHEN GUOFENG (CN)
FENG CHUNLAN (CN)
LIU JIAYUAN (CN)
YANG TAO (CN)
Application Number:
PCT/CN2023/116894
Publication Date:
March 14, 2024
Filing Date:
September 05, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D315/00; A61K31/7048; A61P11/06; A61P17/00; A61P25/16; A61P25/24; A61P25/28
Foreign References:
| CN105732598A | 2016-07-06 | |||
| CN112823798A | 2021-05-21 | |||
| JP2010138081A | 2010-06-24 |
Other References:
DATABASE REGISTRY 21 September 2015 (2015-09-21), ANONYMOUS: "2(3H)-Furanone, 3-[[4-[(6-O-D-apio-β-D-furanosyl-β-D-glucopyranosyl)oxy]-3-m ethoxyphenyl]methyl]-4-[(3,4-dimethoxyphenyl)methyl]dihydro-, (3R,4R)- (CA INDEX NAME)", XP093147499, retrieved from STNext Database accession no. 1807808-85-0
KIM HYE-YOOM, YOON JUNG-JOO, KIM DAE-SUNG, KANG DAE-GILL, LEE HO-SUB: "YG-1 Extract Improves Acute Pulmonary Inflammation by Inducing Bronchodilation and Inhibiting Inflammatory Cytokines", NUTRIENTS, M D P I AG, CH, vol. 13, no. 10, 1 October 2021 (2021-10-01), CH , pages 3414, XP093147074, ISSN: 2072-6643, DOI: 10.3390/nu13103414
LI HENG; ZHANG XIANGLEI; XIANG CAIGUI; FENG CHUNLAN; FAN CHEN; LIU MOTING; LU HUIMIN; SU HAIXIA; ZHOU YU; QI QING; XU YECHUN; TANG: "Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation", JOURNAL OF ADVANCED RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 33, 4 March 2021 (2021-03-04), AMSTERDAM, NL , pages 241 - 251, XP086789938, ISSN: 2090-1232, DOI: 10.1016/j.jare.2021.02.006
KIM HYE-YOOM, YOON JUNG-JOO, KIM DAE-SUNG, KANG DAE-GILL, LEE HO-SUB: "YG-1 Extract Improves Acute Pulmonary Inflammation by Inducing Bronchodilation and Inhibiting Inflammatory Cytokines", NUTRIENTS, M D P I AG, CH, vol. 13, no. 10, 1 October 2021 (2021-10-01), CH , pages 3414, XP093147074, ISSN: 2072-6643, DOI: 10.3390/nu13103414
LI HENG; ZHANG XIANGLEI; XIANG CAIGUI; FENG CHUNLAN; FAN CHEN; LIU MOTING; LU HUIMIN; SU HAIXIA; ZHOU YU; QI QING; XU YECHUN; TANG: "Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation", JOURNAL OF ADVANCED RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 33, 4 March 2021 (2021-03-04), AMSTERDAM, NL , pages 241 - 251, XP086789938, ISSN: 2090-1232, DOI: 10.1016/j.jare.2021.02.006
Attorney, Agent or Firm:
BEIJING YUEHE INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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