Title:
DICHLOROACETIC-ACID-COUPLED DIPHENYLETHANE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/123695
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of drug synthesis, and particularly relates to a dichloroacetic-acid-coupled diphenylethane compound, and a preparation method therefor and the use thereof. The structure of the dichloroacetic-acid-coupled diphenylethane compound of the present invention is as shown in the general formula (I), wherein R1, R2 and R3 are selected from, but not limited to, any one of -OH, -OMe and H; R4 is selected from, but not limited to, any one of -OMe and -OEt; R5 and R6 are selected from chlorine atoms or fluorine atoms; m is 0 or 1; and n is a positive integer selected from 1-8 or 11-12. The dichloroacetic-acid-coupled diphenylethane compound of the present invention has a stable structure, low toxicity, a simple and convenient preparation process and high yield, does not need to be stored in the dark, and has obvious anti-tumor activity on various tumor cells cultured in vitro and significant anti-tumor effects in vivo. The general formula (I) is:
Inventors:
WU FANHONG (CN)
HUANG JINWEN (CN)
XUE KANGYAN (CN)
NIE HUI (CN)
LIU FULI (CN)
TANG HUI (CN)
HUANG JINWEN (CN)
XUE KANGYAN (CN)
NIE HUI (CN)
LIU FULI (CN)
TANG HUI (CN)
Application Number:
PCT/CN2022/081328
Publication Date:
July 06, 2023
Filing Date:
March 17, 2022
Export Citation:
Assignee:
SHANGHAI ECUSTBIOMEDICINECOMPANY LTD (CN)
International Classes:
C07C69/36; A61K31/22; A61K31/223; A61P35/00; A61P35/02; C07C67/14; C07C231/12; C07C233/47
Foreign References:
| CN114230466A | 2022-03-25 | |||
| CN112851561A | 2021-05-28 | |||
| US20180369190A1 | 2018-12-27 | |||
| US20160367498A1 | 2016-12-22 | |||
| CN113501783A | 2021-10-15 | |||
| CN110958998A | 2020-04-03 | |||
| CN103864750A | 2014-06-18 |
Other References:
TANAKA YURI, SUZUKI MARINA, KODACHI YUKA, NIHEI KEN-ICHI: "Molecular design of potent, hydrophilic tyrosinase inhibitors based on the natural dihydrooxyresveratrol skeleton", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 472, 1 January 2019 (2019-01-01), GB , pages 42 - 49, XP093074770, ISSN: 0008-6215, DOI: 10.1016/j.carres.2018.11.006
ZHU, YU ET AL.: "Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 143, 10 October 2017 (2017-10-10), XP085306007, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.10.014
ZHU, YU ET AL.: "Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 143, 10 October 2017 (2017-10-10), XP085306007, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.10.014
Attorney, Agent or Firm:
SHANGHAI ZHI XIN PATENT AGENT LTD. (CN)
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