Title:
DIFFERENTIAL CXCR4 EXPRESSION ON HEMATOPOIETIC PROGENITOR CELLS VERSUS STEM CELLS DIRECTS HOMING AND LONG-TERM ENGRAFTMENT
Document Type and Number:
WIPO Patent Application WO/2023/288220
Kind Code:
A3
Abstract:
Compositions and methods for delivering a protein of interest such as a cell homing molecule (e.g., CXCR4) into host cells (e.g., to hematopoietic cells). The compositions and methods provided herein may be used to enhance homing and long-term engraftment of hematopoietic cells post transplantation.
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Inventors:
MALIK PUNAM (US)
Application Number:
PCT/US2022/073641
Publication Date:
February 08, 2024
Filing Date:
July 12, 2022
Export Citation:
Assignee:
CHILDRENS HOSPITAL MED CT (US)
International Classes:
A61K35/28; A61P7/00
Domestic Patent References:
| WO2021119539A1 | 2021-06-17 |
Other References:
KÜBLER JENS, KIRSCHNER STEFANIE, HARTMANN LINDA, WELZEL GRIT, ENGELHARDT MAREN, HERSKIND CARSTEN, VELDWIJK MARLON R, SCHULTZ CHRIS: "The HIV-derived protein Vpr 52-96 has anti-glioma activity in vitro and in vivo", ONCOTARGET, vol. 7, no. 29, 2 June 2016 (2016-06-02), pages 45500 - 45512, XP093138262, DOI: 10.18632/oncotarget.9787
SELIG L, BENICHOU S, ROGEL M E, WU L I, VODICKA M A, SIRE J, BENAROUS R, EMERMAN M: "Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 6, 1 June 1997 (1997-06-01), US , pages 4842 - 4846, XP093138268, ISSN: 0022-538X, DOI: 10.1128/jvi.71.6.4842-4846.1997
FELKER SYDNEY, SHRESTHA ARCHANA, BAILEY JEFF, PILLIS DEVIN M, SINIARD DYLAN, MALIK PUNAM: "Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment", JCI INSIGHT, vol. 7, no. 9, 9 May 2022 (2022-05-09), XP093036111, DOI: 10.1172/jci.insight.151847
SELIG L, BENICHOU S, ROGEL M E, WU L I, VODICKA M A, SIRE J, BENAROUS R, EMERMAN M: "Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 6, 1 June 1997 (1997-06-01), US , pages 4842 - 4846, XP093138268, ISSN: 0022-538X, DOI: 10.1128/jvi.71.6.4842-4846.1997
FELKER SYDNEY, SHRESTHA ARCHANA, BAILEY JEFF, PILLIS DEVIN M, SINIARD DYLAN, MALIK PUNAM: "Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment", JCI INSIGHT, vol. 7, no. 9, 9 May 2022 (2022-05-09), XP093036111, DOI: 10.1172/jci.insight.151847
Attorney, Agent or Firm:
CHEN, Yahua (US)
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