Title:
DIFFERENTIATION OF IMMUNOCYTES USING PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2019/117444
Kind Code:
A1
Abstract:
The present invention relates to a method for inducing differentiation of hematopoietic stem cells or macrophages by using pluripotent stem cells, and a composition for inducing differentiation. Specifically, the present invention relates to a composition for inducing differentiation of hematopoietic stem cells comprising bone morphogenetic protein 4 (BMP4) in pluripotent stem cells, or a composition for inducing differentiation of macrophages comprising BMP4 and a macrophage-colony stimulating factor (M-CSF), and a method for inducing differentiation by using the compositions. The method for inducing differentiation of the present invention is advantageous in that a differentiation method thereof is simple since only a few types of cytokine are used, and compared to conventional differentiation inducing methods, the efficiency of differentiation is improved tens of times or more and the yield of differentiated cells is high.
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Inventors:
KIM JUNG HYUN (KR)
HAN HYO WON (KR)
SEO HYANG HEE (KR)
HAN HYO WON (KR)
SEO HYANG HEE (KR)
Application Number:
PCT/KR2018/012065
Publication Date:
June 20, 2019
Filing Date:
October 12, 2018
Export Citation:
Assignee:
KOREA CENTER DISEASE CONTROL & PREVENTION (KR)
International Classes:
C12N5/0786
Domestic Patent References:
| WO2016114723A1 | 2016-07-21 |
Foreign References:
| KR20110122858A | 2011-11-11 | |||
| US20140328809A1 | 2014-11-06 | |||
| KR20150124717A | 2015-11-06 | |||
| KR101738508B1 | 2017-05-22 |
Attorney, Agent or Firm:
CHOI, Eun Sun (KR)
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