Title:
DIFFERENTIATION PROMOTER FOR PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2019/182044
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a material for efficiently obtaining differentiated cells from pluripotent stem cells. Specifically, the present invention provides: a differentiation promoter for pluripotent stem cells that is characterized by having, as an active ingredient, β-nicotinamide mononucleotide, a pharmacologically acceptable salt thereof, or a solvate of either; and a method for causing pluripotent stem cells to differentiate that is characterized in that pluripotent stem cells are cultivated in a culture medium containing β-nicotinamide mononucleotide, a pharmacologically acceptable salt thereof, or a solvate of either.
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Inventors:
MATSUO HIDENORI (JP)
GA AYUMI (JP)
YAMADA MUNEHIRO (JP)
TOMIMORI YOSHIYA (JP)
GA AYUMI (JP)
YAMADA MUNEHIRO (JP)
TOMIMORI YOSHIYA (JP)
Application Number:
PCT/JP2019/011827
Publication Date:
September 26, 2019
Filing Date:
March 20, 2019
Export Citation:
Assignee:
ORIENTAL YEAST CO LTD (JP)
International Classes:
C12N5/0735; C12N1/38; C12N5/074; C12N5/0775; C12N5/0789; C12N5/0797; C12N5/10; A61K31/706
Domestic Patent References:
| WO2018143258A1 | 2018-08-09 |
Foreign References:
| JP2018055186A | 2018-04-05 | |||
| JP2010524457W | ||||
| JP2015507921W | ||||
| IB2011102333W | ||||
| US7737158B2 | 2010-06-15 | |||
| IB2014146044W |
Other References:
ZHAO, YAN ET AL.: "Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade", STROKE, vol. 46, no. 7, 9 June 2015 (2015-06-09), pages 1966 - 1974, XP055530690, DOI: 10.1161/STROKEAHA.115.009216
MATSUO, HIDENORI ET AL.: "Effect of beta-Nicotinamide mononucleotide in human pluripotent stem cells", LECTURE ABSTRACTS OF THE ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, vol. 90
MENG, YA ET AL.: "Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells", STEM CELL REPORTS, vol. 11, no. 6, 11 December 2018 (2018-12-11), pages 1347 - 1356, XP055641197
SON ET AL., STEM CELLS, vol. 31, 2013, pages 1121 - 1135
MATSUO, HIDENORI ET AL.: "Effect of beta-Nicotinamide mononucleotide in human pluripotent stem cells", LECTURE ABSTRACTS OF THE ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, vol. 90
MENG, YA ET AL.: "Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells", STEM CELL REPORTS, vol. 11, no. 6, 11 December 2018 (2018-12-11), pages 1347 - 1356, XP055641197
SON ET AL., STEM CELLS, vol. 31, 2013, pages 1121 - 1135
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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