Title:
DIHYDRONAPHTHALENE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2016/088834
Kind Code:
A1
Abstract:
A compound shown by general formula (I) (in the formula, all of the symbols are as defined in the specification) has selective S1P5 receptor agonist activity due to having a linker from a phenyl group to a cyclic substituent in a dihydronaphthalene skeleton; i.e., due to having a short linker of one atom or less as L in general formula (I), and can therefore serve as an agent for the treatment of S1P5-mediated diseases, e.g., neurodegenerative diseases such as schizophrenia.
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Inventors:
KUSUMI KENSUKE (JP)
KURATA HARUTO (JP)
NAGANAWA ATSUSHI (JP)
KODERA YASUYO (JP)
INAGAKI YUICHI (JP)
TAKIZAWA HIROYA (JP)
WOLF MARK ALLAN (US)
RAKER JOSEPH (US)
KURATA HARUTO (JP)
NAGANAWA ATSUSHI (JP)
KODERA YASUYO (JP)
INAGAKI YUICHI (JP)
TAKIZAWA HIROYA (JP)
WOLF MARK ALLAN (US)
RAKER JOSEPH (US)
Application Number:
PCT/JP2015/084019
Publication Date:
June 09, 2016
Filing Date:
December 03, 2015
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
C07D205/04; A61K31/397; A61P25/28; A61P31/00; A61P35/00; A61P37/02; A61P43/00; C07D207/16
Domestic Patent References:
| WO2005020882A2 | 2005-03-10 | |||
| WO2006064757A1 | 2006-06-22 |
Foreign References:
| JP2013501074A | 2013-01-10 |
Other References:
ITOH, K. ET AL., CHEM. PHARM. BULL., vol. 31, no. 6, 1983, pages 2006 - 2015, XP003032452
See also references of EP 3228615A4
See also references of EP 3228615A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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