Title:
DIHYDROOROTATE DEHYDROGENASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2003/030905
Kind Code:
A1
Abstract:
A compound represented by the formula (I): wherein R1 and R4 each independently is alkyl or alkoxy&semi R2 and R3 each independently is hydrogen or alkyl&semi R5 is hydrogen or halogeno&semi R6 is hydrogen or hydroxy&semi and X1 and X2 each independently is −O− or −NH−. The compound was found to have dihydroorotate dehydrogenase inhibitory activity.
Inventors:
ARIMURA AKINORI (JP)
KISHINO JUNJI (JP)
TANIMOTO NORIHIKO (JP)
KISHINO JUNJI (JP)
TANIMOTO NORIHIKO (JP)
Application Number:
PCT/JP2002/010030
Publication Date:
April 17, 2003
Filing Date:
September 27, 2002
Export Citation:
Assignee:
SHIONOGI & CO (JP)
ARIMURA AKINORI (JP)
KISHINO JUNJI (JP)
TANIMOTO NORIHIKO (JP)
ARIMURA AKINORI (JP)
KISHINO JUNJI (JP)
TANIMOTO NORIHIKO (JP)
International Classes:
A61P1/04; A61P11/06; A61P17/00; A61P17/06; A61P21/04; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P41/00; A61P43/00; C07D213/64; (IPC1-7): A61K31/4418; A61P1/04; A61P11/06; A61P17/00; A61P17/06; A61P21/04; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P41/00; A61P43/00; C07D213/64; C07D213/74
Domestic Patent References:
| WO2002057237A1 | 2002-07-25 |
Foreign References:
| EP1052238A1 | 2000-11-15 | |||
| EP1206935A1 | 2002-05-22 |
Other References:
SUTTON A.E.; CLARDY J.: "The synthesis of potentially selective inhibitors of dihydroorotate dehydrogenase. The utilization of chemoselective Suzuki cross-coupling reactions in a parallelsynthetis", TETRAHEDRON LETTERS, vol. 42, no. 4, 22 January 2001 (2001-01-22), pages 547 - 551, XP004314731
Attorney, Agent or Firm:
Yamauchi, Hideaki (Ltd. Intellectual Property Department 12-4,
Sagisu 5-chome, Fukushima-k, Osaka-shi Osaka, JP)
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