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Document Type and Number:
WIPO Patent Application WO/2013/180140
Kind Code:
The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor that is applicable to various diseases. As an active ingredient, a compound represented by formula (I) (wherein X represents a halogen atom; R1 represents a hydrogen atom; R2 represents an alkyl group having 1 to 7 carbon atoms; R3 represents -CHO; and R4 represents -CH2-CH=C(CH3)-R0 (wherein R0 represents an alkyl group having 1 to 12 carbon atoms which may have a substituent on a terminal carbon atom and/or a non-terminal carbon atom, or the like)), an optical isomer of the compound, and a pharmaceutically acceptable salt of the compound or the optical isomer. The compound, the optical isomer and the pharmaceutically acceptable salt have an excellent inhibitory activity on dihydroorotic acid dehydrogenase and therefore can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anti-cancer agent, a therapeutic agent for rejection response, an anti-viral agent, an anti-H. pylori agent, a therapeutic agent for diabetes and the like.

Application Number:
Publication Date:
December 05, 2013
Filing Date:
May 28, 2013
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International Classes:
A61K31/11; A61K9/08; A61K31/121; A61K31/216; A61K31/222; A61K31/336; A61K31/341; A61K31/351; A61K31/357; A61K47/10; A61P1/04; A61P3/10; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/06; A61P43/00; C07C47/56; C07C47/565; C07C47/575; C07C49/258; C07C69/14; C07C69/24; C07C69/738; C07D303/14; C07D307/20; C07D309/12
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Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
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