Title:
DIPEPTIDYL PEPTIDASE IV (DDP IV) INHIBITORS, PREPARATION METHODS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/006211
Kind Code:
A1
Abstract:
Dipeptidyl peptidase IV inhibitors of the following general formula are provided. And
the said inhibitors are proved to be capable of effectively inhibiting the activity
of DDPIV, and can be used for the prophylaxis, delay or treatment of the diseases
mediated by DDPIV, especially diabetes type I and II, impaired glucose tolerance
(IGT), obesity, arthritis, osteoporosis and some tumors. The preparation methods
of the present inhibitors are also provided.(formula)
Inventors:
LI JIA (CN)
NAN FAJUN (CN)
GU MING (CN)
LI JINGYA (CN)
YI HUA (CN)
LI YUANYUAN (CN)
NAN FAJUN (CN)
GU MING (CN)
LI JINGYA (CN)
YI HUA (CN)
LI YUANYUAN (CN)
Application Number:
PCT/CN2006/001596
Publication Date:
January 18, 2007
Filing Date:
July 06, 2006
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
LI JIA (CN)
NAN FAJUN (CN)
GU MING (CN)
LI JINGYA (CN)
YI HUA (CN)
LI YUANYUAN (CN)
LI JIA (CN)
NAN FAJUN (CN)
GU MING (CN)
LI JINGYA (CN)
YI HUA (CN)
LI YUANYUAN (CN)
International Classes:
C07D495/14; A61K31/519; A61P3/04; A61P3/10; A61P19/10; A61P35/00; C07D471/14; C07D491/048
Domestic Patent References:
| WO2005037779A2 | 2005-04-28 |
Foreign References:
| US4472400A | 1984-09-18 |
Other References:
EL-GAZZAR A B A ET AL.: "Synthesis of polynuclear heterocyclic compounds derived from Thieno[2,3-d]pyrimidine derivatives", MOLECULES, vol. 5, no. 6, 18 September 1984 (1984-09-18), pages 835 - 850, XP008076500
DATABASE CAPLUS 14 September 2000 (2000-09-14), KHRIPAK S.M. ET AL.: "Preparation of triazolothienopyrimidine derivatives", XP003007881
DATABASE CAPLUS 11 September 2001 (2001-09-11), HAMED, ATEF A. ET AL.: "4',x-Seco and 4',x-4',5'-diseco C-nucleosides from 2-hydrazino-(3H)-thieno[2,3-d]pyrimidin-4-ones", XP003007882
DATABASE CAPLUS 1978, LALEZARI I, JABARI-SAHBARI M.H.: "New polyheterocyclic series based on 4,5,6,7-tethrahydrothieno[2,3-c]pyridine", XP003007883
DATABASE CAPLUS 1992, PATHAK U.S. ET AL.: "Synthesis of some [1,2,4]triazolo[4,3-s]thieno[3,2-e]pyrimidin-5(4H9-ones", XP003007884
DATABASE CAPLUS 14 September 2000 (2000-09-14), KHRIPAK S.M. ET AL.: "Preparation of triazolothienopyrimidine derivatives", XP003007881
DATABASE CAPLUS 11 September 2001 (2001-09-11), HAMED, ATEF A. ET AL.: "4',x-Seco and 4',x-4',5'-diseco C-nucleosides from 2-hydrazino-(3H)-thieno[2,3-d]pyrimidin-4-ones", XP003007882
DATABASE CAPLUS 1978, LALEZARI I, JABARI-SAHBARI M.H.: "New polyheterocyclic series based on 4,5,6,7-tethrahydrothieno[2,3-c]pyridine", XP003007883
DATABASE CAPLUS 1992, PATHAK U.S. ET AL.: "Synthesis of some [1,2,4]triazolo[4,3-s]thieno[3,2-e]pyrimidin-5(4H9-ones", XP003007884
Attorney, Agent or Firm:
SHANGHAI KAIJI INTELLECTUAL PROPERTY AGENT CO., LTD. (188 Nandandong Road, Shanghai 0, CN)
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