Title:
DIPEPTIDYL PEPTIDASE IV INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2002/051836
Kind Code:
A1
Abstract:
A compound represented by the general formula (I): A-B-D or a pharmacologically acceptable salt of the compound.
Inventors:
MATSUNO KENJI (JP)
UENO KIMIHISA (JP)
IWATA YASUHIRO (JP)
MATSUMOTO YUICHI (JP)
NAKANISHI SATOSHI (JP)
TAKASAKI KOTARO (JP)
KUSAKA HIDEAKI (JP)
NOMOTO YUJI (JP)
OGAWA AKIRA (JP)
UENO KIMIHISA (JP)
IWATA YASUHIRO (JP)
MATSUMOTO YUICHI (JP)
NAKANISHI SATOSHI (JP)
TAKASAKI KOTARO (JP)
KUSAKA HIDEAKI (JP)
NOMOTO YUJI (JP)
OGAWA AKIRA (JP)
Application Number:
PCT/JP2001/011578
Publication Date:
July 04, 2002
Filing Date:
December 27, 2001
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
MATSUNO KENJI (JP)
UENO KIMIHISA (JP)
IWATA YASUHIRO (JP)
MATSUMOTO YUICHI (JP)
NAKANISHI SATOSHI (JP)
TAKASAKI KOTARO (JP)
KUSAKA HIDEAKI (JP)
NOMOTO YUJI (JP)
OGAWA AKIRA (JP)
MATSUNO KENJI (JP)
UENO KIMIHISA (JP)
IWATA YASUHIRO (JP)
MATSUMOTO YUICHI (JP)
NAKANISHI SATOSHI (JP)
TAKASAKI KOTARO (JP)
KUSAKA HIDEAKI (JP)
NOMOTO YUJI (JP)
OGAWA AKIRA (JP)
International Classes:
A61P1/04; A61P1/14; A61P3/06; A61P3/10; A61P9/10; A61P15/00; A61P15/08; A61P19/02; A61P31/18; A61P37/06; A61P43/00; C07D207/16; C07D401/12; C07D401/14; C07D403/12; C07D417/12; C07D417/14; (IPC1-7): C07D401/12; C07D417/12; C07D401/14; C07D403/12; C07D405/12; C07D207/16; C07D417/14; A61K31/4709; A61K31/4725; A61K31/428; A61K31/4439; A61K31/496; A61K31/4545; A61K31/497; A61K31/498; A61K31/506; A61K31/433; A61K31/502; A61K31/501; A61K31/5377; A61K31/517; A61K31/4025; A61K31/454; A61P43/00; A61P3/10; A61P3/06; A61P9/10; A61P15/08; A61P15/00; A61P19/02; A61P37/06; A61P31/18; A61P1/04; A61P1/14
Domestic Patent References:
| WO2001096295A2 | 2001-12-20 | |||
| WO2000034241A1 | 2000-06-15 | |||
| WO1995031442A1 | 1995-11-23 | |||
| WO1999006397A2 | 1999-02-11 | |||
| WO1992002498A1 | 1992-02-20 |
Foreign References:
| US6011155A | 2000-01-04 | |||
| JP2000511559A | 2000-09-05 | |||
| US6107317A | 2000-08-22 | |||
| FR2152441A1 | 1973-04-27 | |||
| JPH11106375A | 1999-04-20 | |||
| JPH0245464A | 1990-02-15 | |||
| JPS62185068A | 1987-08-13 | |||
| JPS6163669A | 1986-04-01 | |||
| JPH0971564A | 1997-03-18 | |||
| JPH02229162A | 1990-09-11 |
Other References:
HUGHES THOMAS E. ET AL.: "NVP-DPP728(1-(((2-(5-cyanopyridin-2-yl)amino)ethyl)amino)acetyl)-2-cyano-(S)-pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV", BIOCHEMISTRY, vol. 38, no. 36, 1999, pages 11597 - 11603, XP002184055
TOLL LAWRENCE, ALMQUIST RONALD G.: "Inhibition of (3H)captopril binding by peptide analog angiotensin converting enzyme inhibitors", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 135, no. 3, 1986, pages 770 - 777, XP002909413
ALMQUIST RONALD G. ET AL.: "Synthesis and biological activity of an amino analog of a tripeptide inhibitor of angiotensin-converting enzyme", J. PHARM. SCI., vol. 72, no. 1, 1983, pages 63 - 67, XP002909414
VALENTA VLADIMIR ET AL.: "Potential nootropic agents: synthesis of a series of (2-oxo-1-pyrrolidinyl)acetic acid piperazides", COLLECT. CZECH. CHEM. COMMUN., vol. 55, no. 6, 1990, pages 1613 - 1629, XP002909415
GANDOLFI CARMELO A. ET AL.: "N-acyl-2-substituted-1,3-thiazolidines, a new class of non-narcotic antitussive agents: studies leading to the discovery of ethyl 2-((2-methoxyphenoxy)methyl)-beta-oxothiazolidine-3-propanoate", J. MED. CHEM., vol. 38, no. 3, 1995, pages 508 - 525, XP002909416
DE JULIAN-ORTIZ ET AL.: "Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds", J. MED. CHEM., vol. 42, no. 17, 1999, pages 3308 - 3314, XP002909417
OTAKA HIROSHI ET AL.: "Benzylpiperazine derivatives. VIII. Syntheses, antiulcer and cytoprotective activities of 1-(aminocarbonylalkyl)-4-benzylpiperazine derivatives and related compounds", CHEM. PHARM. BULL., vol. 36, no. 10, 1988, pages 3948 - 3954, XP002105884
TOLL LAWRENCE, ALMQUIST RONALD G.: "Inhibition of (3H)captopril binding by peptide analog angiotensin converting enzyme inhibitors", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 135, no. 3, 1986, pages 770 - 777, XP002909413
ALMQUIST RONALD G. ET AL.: "Synthesis and biological activity of an amino analog of a tripeptide inhibitor of angiotensin-converting enzyme", J. PHARM. SCI., vol. 72, no. 1, 1983, pages 63 - 67, XP002909414
VALENTA VLADIMIR ET AL.: "Potential nootropic agents: synthesis of a series of (2-oxo-1-pyrrolidinyl)acetic acid piperazides", COLLECT. CZECH. CHEM. COMMUN., vol. 55, no. 6, 1990, pages 1613 - 1629, XP002909415
GANDOLFI CARMELO A. ET AL.: "N-acyl-2-substituted-1,3-thiazolidines, a new class of non-narcotic antitussive agents: studies leading to the discovery of ethyl 2-((2-methoxyphenoxy)methyl)-beta-oxothiazolidine-3-propanoate", J. MED. CHEM., vol. 38, no. 3, 1995, pages 508 - 525, XP002909416
DE JULIAN-ORTIZ ET AL.: "Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds", J. MED. CHEM., vol. 42, no. 17, 1999, pages 3308 - 3314, XP002909417
OTAKA HIROSHI ET AL.: "Benzylpiperazine derivatives. VIII. Syntheses, antiulcer and cytoprotective activities of 1-(aminocarbonylalkyl)-4-benzylpiperazine derivatives and related compounds", CHEM. PHARM. BULL., vol. 36, no. 10, 1988, pages 3948 - 3954, XP002105884
Attorney, Agent or Firm:
Imamura, Masazumi (Kyobashi-Nisshoku Bldg. 8-, Kyobashi 1-chome Chuo-ku Tokyo, JP)
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