Title:
DIPHENOLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/221665
Kind Code:
A1
Abstract:
The present invention provides a class of compounds derived from resorcinol as represented by formula A. The compound can be used for preparing a drug for inhibiting hyperpigmentation, and can be used cosmetically and non-therapeutically for treating hyperpigmentation. The compounds of the present invention have significant effects on inhibiting pigmentation caused by ultraviolet and/or visible light radiation, and anti-skin aging, etc., wherein W is [formula], T is H, [formula] or [formula], and the definitions of R1 to R8 are as defined in the description.
Inventors:
XING WENLONG (CN)
JIAO TI (CN)
LI SHENGXUE (CN)
WANG ZHIHUI (CN)
JIAO TI (CN)
LI SHENGXUE (CN)
WANG ZHIHUI (CN)
Application Number:
PCT/CN2023/085442
Publication Date:
November 23, 2023
Filing Date:
March 31, 2023
Export Citation:
Assignee:
PURPANA BEIJING TECH CO LTD (CN)
International Classes:
C07D207/27; A61K8/00; A61Q17/04; A61Q19/02; C07C37/00
Domestic Patent References:
| WO2001019323A1 | 2001-03-22 |
Foreign References:
| CN113307725A | 2021-08-27 | |||
| CN104523442A | 2015-04-22 | |||
| CN101175711A | 2008-05-07 |
Other References:
DATABASE Registry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "2H-Azepin-2-one, 1-[(2,4-dihydr oxyphenyl)methyl]hexahydr o-", XP093110362, retrieved from STN Database accession no. 65422-05-1
DATABASE Registry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "2-Piperidinone, 1-[(2,4-dihydrox yphenyl)methyl]-", XP093110363, retrieved from STN Database accession no. 80867-99-8
WEN JINGYUN, QI HAOFEI, KONG XIANGJIN, CHEN LIGONG, YAN XILONG: "Hydroarylation of Styrenes with Electron-Rich Arenes Over Acidic Ion-Exchange Resins", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS INC., US, vol. 44, no. 13, 3 July 2014 (2014-07-03), US , pages 1893 - 1903, XP093110190, ISSN: 0039-7911, DOI: 10.1080/00397911.2013.876547
PRASHANT SHUKLA, MANOJ K. CHOUDHARY, SANDIP K. NAYAK: "Microwave-Accelerated Alkylation of Arenes/Heteroarenes with Benzylic Alcohols Using Antimony(III) Chloride as Catalyst: Synthesis of O-Heterocycles", SYNLETT, GEORG THIEME VERLAG, DE, vol. 11, no. 11, 15 June 2011 (2011-06-15), DE , pages 1585 - 1591, XP009550566, ISSN: 0936-5214, DOI: 10.1055/s-0030-1260795
ROULIER BRAYAN, RUSH INBAL, LAZINSKI LETICIA M., PÉRÈS BASILE, OLLEIK HAMZA, ROYAL GUY, FISHMAN AYELET, MARESCA MARC, HAUDECOEUR R: "Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 246, 1 January 2023 (2023-01-01), AMSTERDAM, NL , pages 114972, XP093110193, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2022.114972
DATABASE Registry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "2-Piperidinone, 1-[(2,4-dihydrox yphenyl)methyl]-", XP093110363, retrieved from STN Database accession no. 80867-99-8
WEN JINGYUN, QI HAOFEI, KONG XIANGJIN, CHEN LIGONG, YAN XILONG: "Hydroarylation of Styrenes with Electron-Rich Arenes Over Acidic Ion-Exchange Resins", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS INC., US, vol. 44, no. 13, 3 July 2014 (2014-07-03), US , pages 1893 - 1903, XP093110190, ISSN: 0039-7911, DOI: 10.1080/00397911.2013.876547
PRASHANT SHUKLA, MANOJ K. CHOUDHARY, SANDIP K. NAYAK: "Microwave-Accelerated Alkylation of Arenes/Heteroarenes with Benzylic Alcohols Using Antimony(III) Chloride as Catalyst: Synthesis of O-Heterocycles", SYNLETT, GEORG THIEME VERLAG, DE, vol. 11, no. 11, 15 June 2011 (2011-06-15), DE , pages 1585 - 1591, XP009550566, ISSN: 0936-5214, DOI: 10.1055/s-0030-1260795
ROULIER BRAYAN, RUSH INBAL, LAZINSKI LETICIA M., PÉRÈS BASILE, OLLEIK HAMZA, ROYAL GUY, FISHMAN AYELET, MARESCA MARC, HAUDECOEUR R: "Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 246, 1 January 2023 (2023-01-01), AMSTERDAM, NL , pages 114972, XP093110193, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2022.114972
Attorney, Agent or Firm:
HERUN-KESHENG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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