Title:
DIPHENYL ALKANE COMPOUND AND PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/194136
Kind Code:
A1
Abstract:
The invention belongs to the technical field of medicine. A soluble berberine-type quaternary ammonium alkaloid compound and the use thereof in preparing a drug are disclosed. In particular, disclosed are a compound as represented by general formula A and a compound that further may be represented specifically by general formulas I and I', a pharmaceutical composition thereof, a preparation method therefor, and the use thereof. The compounds of the present invention have significant activity in treating cardiovascular, cerebrovascular and blood system diseases, inflammatory diseases, febrile diseases, tumor diseases, autoimmune diseases and viral infectious diseases and complications thereof by inhibiting/reducing the activity of biological body pathological NO, iNOS, IL-6 and autoantibody levels, and inhibiting the activity of SARS-COV 2 virus RNA replication. The strength of the physical and chemical properties as well as the pharmacological function of the compounds of the present invention are superior to those of control drugs and related compounds, and can be used for preparing drugs for preventing, alleviating and/or treating cardiovascular, cerebrovascular and blood system diseases, inflammatory diseases, febrile diseases, tumor diseases, autoimmune diseases and viral infection diseases and complications thereof.
Inventors:
QIN HAILIN (CN)
DENG ANJUN (CN)
ZHANG XUEQIAN (CN)
XU LINGWEN (CN)
YAN ZHENG (CN)
LI ZHIHONG (CN)
DENG ANJUN (CN)
ZHANG XUEQIAN (CN)
XU LINGWEN (CN)
YAN ZHENG (CN)
LI ZHIHONG (CN)
Application Number:
PCT/CN2022/080897
Publication Date:
September 22, 2022
Filing Date:
April 13, 2022
Export Citation:
Assignee:
INST OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCICENCES (CN)
International Classes:
A61K31/4375; C07D455/03; A61P3/06; A61P9/10; A61P29/00; A61P31/12; A61P35/00; A61P37/02
Foreign References:
| CN105732609A | 2016-07-06 | |||
| CN103989677A | 2014-08-20 | |||
| CN103919773A | 2014-07-16 | |||
| CN103919775A | 2014-07-16 | |||
| CN1759834A | 2006-04-19 |
Other References:
SHAIKH, A. ET AL.: "Metabolite profiling of arginase inhibitor activity guided fraction of Ficus religiosa leaves by LC–HRMS", BIOMEDICAL CHROMATOGRAPHY, vol. 34, no. 12, 13 August 2020 (2020-08-13), XP071551082, ISSN: 0269-3879, DOI: 10.1002/bmc.4966
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