Title:
DIPHENYLAMINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2005051888
Kind Code:
A3
Abstract:
The invention relates to compounds of the formula (I) in which: i and j=1; R1 is in position 3 or 4 on the phenyl ring and represents a cyano group, an alkoxy group substituted by halogen, a thioalkyl group, an alkylcarbonyl group or an alkylsulfonyl group; and R2 represents a carboxyl group, an aikoxycarbonyl group, an alkylcarbonyl group, an unsubstituted amide group or a linear or branched alkyl group substituted by a cyano, hydroxyl, carboxyl, aikoxycarbonyl or unsubstituted amide group; and also the pharmaceutically acceptable derivatives, salts, solvates and stereoisomers thereof, including mixtures thereof in all proportions.
Inventors:
LARDY CLAUDE (FR)
GUEDAT PHILIPPE
CAPUTO LIDIA (FR)
GUEDAT PHILIPPE
CAPUTO LIDIA (FR)
Application Number:
PCT/EP2004/014916
Publication Date:
August 11, 2005
Filing Date:
November 17, 2004
Export Citation:
Assignee:
MERCK PATENT GMBH (DE)
LARDY CLAUDE (FR)
GUEDAT PHILIPPE
CAPUTO LIDIA (FR)
LARDY CLAUDE (FR)
GUEDAT PHILIPPE
CAPUTO LIDIA (FR)
International Classes:
C07C211/55; C07C215/68; C07C217/92; C07C225/22; C07C229/42; C07C229/60; C07C229/62; C07C233/43; C07C233/65; C07C237/30; C07C255/58; C07C317/36; C07C323/36; (IPC1-7): C07C211/55; C07C205/57; C07C255/57; C07C211/56; C07C317/34; C07C225/10; A61K31/196; A61K31/136; A61K31/145; A61K31/166; A61P3/10; A61P9/10
Domestic Patent References:
| WO2003087045A1 | 2003-10-23 | |||
| WO2003076406A1 | 2003-09-18 |
Foreign References:
| US4316044A | 1982-02-16 | |||
| GB1307284A | 1973-02-14 | |||
| US5196610A | 1993-03-23 |
Other References:
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KIZBER, A. I. ET AL: "Transformations in the series of diazoamino compounds. I. Thermal decomposition of carboxy-substituted diazoaminobenzenes", XP002296498, retrieved from STN Database accession no. 1958:34914
KNOCHEL PAUL: "A New General Preparation of Polyfunctional Diarylamines by the Addition of Functionalized Arylmagnesium Compounds to Nitroarenes", J.AM.CHEM.SOC., no. 124, 2002, pages 9390 - 9391, XP002296494
PATENT ABSTRACTS OF JAPAN vol. 0070, no. 19 (C - 147) 25 January 1983 (1983-01-25)
PATENT ABSTRACTS OF JAPAN vol. 0165, no. 66 (C - 1009) 8 December 1992 (1992-12-08)
PETER J. O'BRIEN: "A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+", TOXYCOLOGY, no. 143, 2000, pages 263 - 273, XP002296495
GÖNÜL SAHIN: "Effects of some probable antioxidants on the selenite-induced cataract formation and oxidative stres-related paramaters in rats", TOXYCOLOGY, no. 139, 1999, pages 219 - 232, XP002296496
JEFFERY W. KELLY: "Synthesis, Structure and Activity of Diclofenac Analogues as Transthyretin Amyloid Fibril Formation Inhibitors", J.MED.CHEM., no. 45, 2002, pages 321 - 332, XP002296497
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002328213, Database accession no. 5061244
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002328214, Database accession no. 2813438
DATABASE CA CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; WARD YANCEY D.: "Solid phase synthesis of aryl amines via palladium catalysed amination of resin-bound aromatic bromides", XP002328215, Database accession no. 1996:605697
DATABASE CA CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BURGER ALFRED: "Some derivatives of 4'-hydroxydiphenylamine-4-carboxylic acid", XP002328216, Database accession no. 1956:44350
MAFFEI FACINO R ET AL: "ANTIOXIDANT PROFILE OF NIMESULIDE, INDOMETHACIN AND DICLOFENAC IN PHOSPHATIDYLCHOLINE LIPOSOMES (PCL) AS MEMBRANE MODEL", INTERNATIONAL JOURNAL OF TISSUE REACTIONS, BIOSCIENCE EDIPRINT, GENEVA, CH, vol. 15, no. 6, 1993, pages 225 - 234, XP002048767, ISSN: 0250-0868
KNOCHEL PAUL: "A New General Preparation of Polyfunctional Diarylamines by the Addition of Functionalized Arylmagnesium Compounds to Nitroarenes", J.AM.CHEM.SOC., no. 124, 2002, pages 9390 - 9391, XP002296494
PATENT ABSTRACTS OF JAPAN vol. 0070, no. 19 (C - 147) 25 January 1983 (1983-01-25)
PATENT ABSTRACTS OF JAPAN vol. 0165, no. 66 (C - 1009) 8 December 1992 (1992-12-08)
PETER J. O'BRIEN: "A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+", TOXYCOLOGY, no. 143, 2000, pages 263 - 273, XP002296495
GÖNÜL SAHIN: "Effects of some probable antioxidants on the selenite-induced cataract formation and oxidative stres-related paramaters in rats", TOXYCOLOGY, no. 139, 1999, pages 219 - 232, XP002296496
JEFFERY W. KELLY: "Synthesis, Structure and Activity of Diclofenac Analogues as Transthyretin Amyloid Fibril Formation Inhibitors", J.MED.CHEM., no. 45, 2002, pages 321 - 332, XP002296497
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002328213, Database accession no. 5061244
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002328214, Database accession no. 2813438
DATABASE CA CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; WARD YANCEY D.: "Solid phase synthesis of aryl amines via palladium catalysed amination of resin-bound aromatic bromides", XP002328215, Database accession no. 1996:605697
DATABASE CA CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BURGER ALFRED: "Some derivatives of 4'-hydroxydiphenylamine-4-carboxylic acid", XP002328216, Database accession no. 1956:44350
MAFFEI FACINO R ET AL: "ANTIOXIDANT PROFILE OF NIMESULIDE, INDOMETHACIN AND DICLOFENAC IN PHOSPHATIDYLCHOLINE LIPOSOMES (PCL) AS MEMBRANE MODEL", INTERNATIONAL JOURNAL OF TISSUE REACTIONS, BIOSCIENCE EDIPRINT, GENEVA, CH, vol. 15, no. 6, 1993, pages 225 - 234, XP002048767, ISSN: 0250-0868
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