Title:
DIRECTED CHEMICAL CONJUGATE OF GLUCAGON-LIKE PEPTIDE-2 MUTANT, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/001313
Kind Code:
A1
Abstract:
A directed chemical conjugate of a glucagon-like peptide-2 mutant, and a use thereof. The glucagon-like peptide-2 mutant performs multiple site mutations and carboxy-terminal extensions on the basis of human glucagon-like peptide-2. By introducing a targeted chemical modification site, the glucagon-like peptide-2 mutant has biological activities consistent with the natural human glucagon-like peptide-2, and meanwhile, the in-vivo half-life period is significantly prolonged, and the drug delivery frequency is reduced, thereby achieving the purpose of treating or preventing intestinal mucosa injury caused by short intestinal syndrome, chemotherapy drugs or radioactive treatment factors, and ulcerative enteritis, chronic enteritis and non-inflammatory bowel injury diseases.
Inventors:
FAN KAI (CN)
PENG YONGLIANG (CN)
CHEN QING (CN)
ZHANG QI (CN)
HE YONG (CN)
QIN XIAOLAN (CN)
SU JIE (CN)
MEI XIN (CN)
ZHAO WENJIE (CN)
PENG YONGLIANG (CN)
CHEN QING (CN)
ZHANG QI (CN)
HE YONG (CN)
QIN XIAOLAN (CN)
SU JIE (CN)
MEI XIN (CN)
ZHAO WENJIE (CN)
Application Number:
PCT/CN2022/112935
Publication Date:
January 26, 2023
Filing Date:
August 17, 2022
Export Citation:
Assignee:
PEG BIO BIOPHARM CO LTD CHONGQING (CN)
International Classes:
C07K14/605; A61K38/26; A61K47/60
Domestic Patent References:
| WO2020165900A1 | 2020-08-20 | |||
| WO2010099746A1 | 2010-09-10 | |||
| WO2020134717A1 | 2020-07-02 |
Foreign References:
| CN1705681A | 2005-12-07 | |||
| CN110545852A | 2019-12-06 | |||
| CN102123723A | 2011-07-13 | |||
| CN101171262A | 2008-04-30 | |||
| US20190330295A1 | 2019-10-31 | |||
| CN111629745A | 2020-09-04 |
Other References:
LAFFERTY RYAN A., O’HARTE FINBARR P. M., IRWIN NIGEL, GAULT VICTOR A., FLATT PETER R.: "Proglucagon-Derived Peptides as Therapeutics", FRONTIERS IN ENDOCRINOLOGY, vol. 12, XP055939985, DOI: 10.3389/fendo.2021.689678
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
Download PDF: