Title:
DISEASE MODEL OF INDUCED PLURIPOTENT STEM CELL (IPSC)-DERIVED TYPE 2 DIABETES MELLITUS, ASSOCIATED WITH CORONARY ARTERY DISEASE
Document Type and Number:
WIPO Patent Application WO/2022/250631
Kind Code:
A3
Abstract:
With this invention, by creating a Diabetes Mellites disease model associated with coronary artery disease from the stimulated pluripotent stem cell source, it is aimed to present a timely-accessed, cost-effective solution to researchers and small-medium-sized pharmaceutical companies conducting antidiabetic drug R & D studies in order to facilitate proceeding from the proof-of-concept phase, to prevent unnecessary R & D costs and to foster the use of fewer animals as disease models.
Inventors:
KILIC PELIN (TR)
TUNCER GIZEM (TR)
KILINC BUGRAHAN REGAIP (TR)
ALTIOK DORUK (TR)
COSAR BEGUM (TR)
TUNCER GIZEM (TR)
KILINC BUGRAHAN REGAIP (TR)
ALTIOK DORUK (TR)
COSAR BEGUM (TR)
Application Number:
PCT/TR2022/050442
Publication Date:
February 09, 2023
Filing Date:
May 18, 2022
Export Citation:
Assignee:
T C ANKARA UNIV REKTORLUGU (TR)
International Classes:
A61K35/12; A61K35/14; A61K35/39; A61K35/545
Foreign References:
| US8257941B2 | 2012-09-04 |
Other References:
HELLER SANDRA, MELZER MICHAEL KARL, AZOITEI NINEL, JULIER CÉCILE, KLEGER ALEXANDER: "Human Pluripotent Stem Cells Go Diabetic: A Glimpse on Monogenic Variants", FRONTIERS IN ENDOCRINOLOGY, vol. 12, XP093034578, DOI: 10.3389/fendo.2021.648284
SZABó ESZTER; REé DóRA; JEZSó BáLINT; VINCZE KATALIN; FöLDES GáBOR; MOLNáR ANDREA Á.;: "Generation of iPSC lines from peripheral blood mononuclear cells of identical twins both suffering from type 2 diabetes mellitus and one of them additionally diagnosed with atherosclerosis", STEM CELL RESEARCH, ELSEVIER, NL, vol. 49, 15 October 2020 (2020-10-15), NL , XP086414409, ISSN: 1873-5061, DOI: 10.1016/j.scr.2020.102051
SZABó ESZTER; REé DóRA; JEZSó BáLINT; VINCZE KATALIN; FöLDES GáBOR; MOLNáR ANDREA Á.;: "Generation of iPSC lines from peripheral blood mononuclear cells of identical twins both suffering from type 2 diabetes mellitus and one of them additionally diagnosed with atherosclerosis", STEM CELL RESEARCH, ELSEVIER, NL, vol. 49, 15 October 2020 (2020-10-15), NL , XP086414409, ISSN: 1873-5061, DOI: 10.1016/j.scr.2020.102051
Attorney, Agent or Firm:
KAYA, Erdem (TR)
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