Title:
DISEASE-RESISTANT TRANSGENIC BIRD CAPABLE OF EXPRESSING FOREIGN RNA
Document Type and Number:
WIPO Patent Application WO/2010/125656
Kind Code:
A1
Abstract:
Disclosed is a disease-resistant transgenic bird which can express functional RNA, particularly shRNA. Also disclosed is a transgenic bird having an enhanced virus-inhibiting effect. Further disclosed is a disease-resistant transgenic bird which can express functional RNA, particularly shRNA, effective against mutant viruses.
A transgenic bird having resistance against an avian pathogenic virus can be produced by using a non-avian-derived retrovirus vector defective in replication ability.
Inventors:
WATANABE HIROYUKI (JP)
Application Number:
PCT/JP2009/058410
Publication Date:
November 04, 2010
Filing Date:
April 28, 2009
Export Citation:
Assignee:
KANEKA CORP (JP)
WATANABE HIROYUKI (JP)
WATANABE HIROYUKI (JP)
International Classes:
C12N15/09; A01K67/027
Foreign References:
| JP2002176880A | 2002-06-25 | |||
| JP2007089578A | 2007-04-12 |
Other References:
CHEN, M ET AL.: "Inhibition of Marek's disease virus replication by retroviral vector-based RNA interference.", VIROLOGY., vol. 377, no. 2, 1 August 2008 (2008-08-01), pages 265 - 272, XP022776760, DOI: doi:10.1016/j.virol.2008.03.019
CHEN, M ET AL.: "Inhibition of avian leukosis virus replication by vector-based RNA interference.", VIROLOGY., vol. 365, no. 2, 1 September 2007 (2007-09-01), pages 464 - 472, XP022196436, DOI: doi:10.1016/j.virol.2007.04.013
ZHOU, K ET AL.: "RNA interference of avian influenza virus H5Nl by inhibiting viral mRNA with siRNA expression plasmids.", J BIOTECHNOL., vol. 135, no. 2, 1 June 2008 (2008-06-01), pages 140 - 144, XP022678775, DOI: doi:10.1016/j.jbiotec.2008.03.007
O'NEILL, G: "Australia tackles bird flu using RNAi.", NAT BIOTECHNOL., vol. 25, no. 6, June 2007 (2007-06-01), pages 605 - 606
CHEN, M ET AL.: "Inhibition of avian leukosis virus replication by vector-based RNA interference.", VIROLOGY., vol. 365, no. 2, 1 September 2007 (2007-09-01), pages 464 - 472, XP022196436, DOI: doi:10.1016/j.virol.2007.04.013
ZHOU, K ET AL.: "RNA interference of avian influenza virus H5Nl by inhibiting viral mRNA with siRNA expression plasmids.", J BIOTECHNOL., vol. 135, no. 2, 1 June 2008 (2008-06-01), pages 140 - 144, XP022678775, DOI: doi:10.1016/j.jbiotec.2008.03.007
O'NEILL, G: "Australia tackles bird flu using RNAi.", NAT BIOTECHNOL., vol. 25, no. 6, June 2007 (2007-06-01), pages 605 - 606
Attorney, Agent or Firm:
KANEKA CORPORATION (JP)
KANEKA Co. (JP)
KANEKA Co. (JP)
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