Title:
DISULFIDE AND THIOSULFONATE LIGANDS AND LIBRARIES COMPRISING THESE LIGANDS
Document Type and Number:
WIPO Patent Application WO/2003/014072
Kind Code:
A1
Abstract:
The present invention provides compounds and libraries of compounds having formula (I), wherein L and n are defined as in the claims and A is -S(CH¿2?)¿p?R?A1¿ or -S(O)¿2?R?A2¿ with p, R?A1¿ and R?A2¿ as defined in the claims. The libraries comprising compounds of formula (I) are useful in the drug discovery process.
Inventors:
BRAISTED ANDREW C (US)
ERLANSON DANIEL A (US)
JACOBS JEFFREY W (US)
ERLANSON DANIEL A (US)
JACOBS JEFFREY W (US)
Application Number:
PCT/US2002/014778
Publication Date:
February 20, 2003
Filing Date:
May 10, 2002
Export Citation:
Assignee:
SUNESIS PHARMACEUTICALS INC (US)
BRAISTED ANDREW C (US)
ERLANSON DANIEL A (US)
JACOBS JEFFREY W (US)
BRAISTED ANDREW C (US)
ERLANSON DANIEL A (US)
JACOBS JEFFREY W (US)
International Classes:
C07C381/04; C07D205/04; C07D207/16; C07D207/46; C07D207/48; C07D211/60; C07D211/62; C07D211/90; C07D211/96; C07D217/26; C07D231/40; C07D277/20; C07D277/46; C07D277/56; C07D307/54; C07D333/24; C07D333/38; C07D401/04; C07D405/14; C07D417/04; (IPC1-7): C07C323/00; C07C323/25; C07C335/08; C07C381/04; C07D205/04; C07D207/08; C07D207/12; C07D211/60; C07D211/62; C07D241/04; C07D263/16; C07D263/34; C07D217/26; C07D413/04; G01N33/53
Domestic Patent References:
| WO2002042773A2 | 2002-05-30 | |||
| WO1998052619A2 | 1998-11-26 | |||
| WO1999049314A1 | 1999-09-30 |
Foreign References:
| US6335155B1 | 2002-01-01 | |||
| EP0117693A2 | 1984-09-05 | |||
| GB1576161A | 1980-10-01 |
Other References:
ERLANSON DANIEL A ET AL: "Site-directed ligand discovery", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 17, 15 August 2000 (2000-08-15), pages 9367 - 9372, XP002199107, ISSN: 0027-8424
HOVINEN, JARI ET AL: "Novel solid supports for the preparation of 3'-derivatized oligonucleotides: introduction of 3'-alkylphosphate tether groups bearing amino, carboxy, carboxamido, and mercapto functionalities", TETRAHEDRON (1994), 50(24), 7203-18, XP002209588
ICHIKAWA, M. ET AL: "A mechanism-based affinity-labeling agent for possible use in isolating N-acetylglucosaminidase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001), 11(13), 1769-1773, XP002209589
JANDA, KIM D. ET AL: "Chemical selection for catalysis in combinatorial antibody libraries", SCIENCE (WASHINGTON, D. C.) (1997), 275(5302), 945-948, XP002209590
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GRIVNAK, L. M. ET AL: "Thiosulfonic acids. XIX. Thiosulfonic acid esters containing hydrazide hydrazone groups", XP002209592, retrieved from STN Database accession no. 68:68584
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GRIVNAK, L. M. ET AL: "Thiosulfonic acids. XVII. Derivatives of carboxymethyl esters of thiosulfonic acids", XP002209593, retrieved from STN Database accession no. 68:21644
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VODOLAZSKAYA, N. A. ET AL: "Antitumor activity of some esters of thiosulfonic acids, including the thio analogs and homologs of Myleran", XP002209594, retrieved from STN Database accession no. 66:36436
PATENT ABSTRACTS OF JAPAN vol. 1996, no. 12 26 December 1996 (1996-12-26)
SPURA, ARMIN ET AL: "Biotinylation of substituted cysteines in the nicotinic acetylcholine receptor reveals distinct binding modes for.alpha.-bungarotoxin and erabutoxin a", JOURNAL OF BIOLOGICAL CHEMISTRY (2000), 275(29), 22452-22460, XP002209591
HANEFELD, WOLFGANG ET AL: "Oxidation of thiocarbamidates. 10..alpha.-Carbamoyl sulfoxides and sulfones. 2. Formation of thiosulfonates by hydrolysis of cyclic.alpha.-carbamoyl sulfoxides", LIEBIGS ANN. CHEM. (1986), (10), 1787-95, XP001093949
HOVINEN, JARI ET AL: "Novel solid supports for the preparation of 3'-derivatized oligonucleotides: introduction of 3'-alkylphosphate tether groups bearing amino, carboxy, carboxamido, and mercapto functionalities", TETRAHEDRON (1994), 50(24), 7203-18, XP002209588
ICHIKAWA, M. ET AL: "A mechanism-based affinity-labeling agent for possible use in isolating N-acetylglucosaminidase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001), 11(13), 1769-1773, XP002209589
JANDA, KIM D. ET AL: "Chemical selection for catalysis in combinatorial antibody libraries", SCIENCE (WASHINGTON, D. C.) (1997), 275(5302), 945-948, XP002209590
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GRIVNAK, L. M. ET AL: "Thiosulfonic acids. XIX. Thiosulfonic acid esters containing hydrazide hydrazone groups", XP002209592, retrieved from STN Database accession no. 68:68584
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GRIVNAK, L. M. ET AL: "Thiosulfonic acids. XVII. Derivatives of carboxymethyl esters of thiosulfonic acids", XP002209593, retrieved from STN Database accession no. 68:21644
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VODOLAZSKAYA, N. A. ET AL: "Antitumor activity of some esters of thiosulfonic acids, including the thio analogs and homologs of Myleran", XP002209594, retrieved from STN Database accession no. 66:36436
PATENT ABSTRACTS OF JAPAN vol. 1996, no. 12 26 December 1996 (1996-12-26)
SPURA, ARMIN ET AL: "Biotinylation of substituted cysteines in the nicotinic acetylcholine receptor reveals distinct binding modes for.alpha.-bungarotoxin and erabutoxin a", JOURNAL OF BIOLOGICAL CHEMISTRY (2000), 275(29), 22452-22460, XP002209591
HANEFELD, WOLFGANG ET AL: "Oxidation of thiocarbamidates. 10..alpha.-Carbamoyl sulfoxides and sulfones. 2. Formation of thiosulfonates by hydrolysis of cyclic.alpha.-carbamoyl sulfoxides", LIEBIGS ANN. CHEM. (1986), (10), 1787-95, XP001093949
Attorney, Agent or Firm:
Shair, Karoline K. M. (Hall & Stewart Exchange Place, 53 State Stree, Boston MA, US)
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