Title:
DNA APTAMER SPECIFICALLY BINDING TO LDL, AND USE OF DNA APTAMER
Document Type and Number:
WIPO Patent Application WO/2023/163521
Kind Code:
A1
Abstract:
The present invention relates to a DNA aptamer specifically binding to LDL, and a use of the DNA aptamer. Specifically, the DNA aptamer, according to the present invention, specifically binds to LDL with high affinity and inhibits LDL which is associated with the development of vascular disease and thus may be usefully employed for LDL detection or treatment of vascular disease.
Inventors:
AHN JI YOUNG (KR)
LEE SANG-HEE (KR)
PARK GA-YOUNG (KR)
CHO HEE YOUNG (KR)
LEE SANG-HEE (KR)
PARK GA-YOUNG (KR)
CHO HEE YOUNG (KR)
Application Number:
PCT/KR2023/002589
Publication Date:
August 31, 2023
Filing Date:
February 23, 2023
Export Citation:
Assignee:
HPBIO INC (KR)
International Classes:
C12N15/115; A23L33/10; A61K31/7088; A61P9/00; C12Q1/68; G01N33/92
Foreign References:
| US20200131515A1 | 2020-04-30 | |||
| KR20120006697A | 2012-01-19 | |||
| US20080302666A1 | 2008-12-11 |
Other References:
KLAPAK DANIEL, BROADFOOT SARAH, PENNER GREGORY, SINGH ANUP, INAPURI ESHWAR: "Development of novel aptamers for low-density lipoprotein particle quantification", PLOS ONE, vol. 13, no. 10, 11 October 2018 (2018-10-11), pages e0205460, XP093087942, DOI: 10.1371/journal.pone.0205460
RUDEWICZ-KOWALCZYK DARIA, GRABOWSKA IWONA: "Detection of Low Density Lipoprotein—Comparison of Electrochemical Immuno- and Aptasensor", SENSORS, vol. 21, no. 22, 20 November 2021 (2021-11-20), pages 7733, XP093087945, DOI: 10.3390/s21227733
RUDEWICZ-KOWALCZYK DARIA, GRABOWSKA IWONA: "Detection of Low Density Lipoprotein—Comparison of Electrochemical Immuno- and Aptasensor", SENSORS, vol. 21, no. 22, 20 November 2021 (2021-11-20), pages 7733, XP093087945, DOI: 10.3390/s21227733
Attorney, Agent or Firm:
WETHEPEOPLE IP & LAW FIRM (KR)
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