Title:
DNA-BASED APTAMERS FOR HUMAN CATHEPSIN G
Document Type and Number:
WIPO Patent Application WO2005003347
Kind Code:
A3
Abstract:
The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chaing length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.
Inventors:
PALUMBO MANLIO (IT)
GATTO BARBARA (IT)
PESCADOR RODOLFO (IT)
PORTA ROBERTO (IT)
FERRO LAURA IRIS (IT)
GATTO BARBARA (IT)
PESCADOR RODOLFO (IT)
PORTA ROBERTO (IT)
FERRO LAURA IRIS (IT)
Application Number:
PCT/EP2004/006599
Publication Date:
September 15, 2005
Filing Date:
June 18, 2004
Export Citation:
Assignee:
GENTIUM SPA (IT)
PALUMBO MANLIO (IT)
GATTO BARBARA (IT)
PESCADOR RODOLFO (IT)
PORTA ROBERTO (IT)
FERRO LAURA IRIS (IT)
PALUMBO MANLIO (IT)
GATTO BARBARA (IT)
PESCADOR RODOLFO (IT)
PORTA ROBERTO (IT)
FERRO LAURA IRIS (IT)
International Classes:
A61P7/02; A61P29/00; C12N15/115; A61K38/00; (IPC1-7): C12N15/11; A61K31/711; A61P7/02; A61P29/00
Domestic Patent References:
| WO1992014843A1 | 1992-09-03 |
Foreign References:
| EP0775745A2 | 1997-05-28 |
Other References:
VIANINI E ET AL: "In vitro selection of DNA aptamers that bind L-tyrosinamide.", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, no. 10, October 2001 (2001-10-01), pages 2543 - 2548, XP002262768, ISSN: 0968-0896
BRACHT ET AL: "Isolation and functional characterization of a specific cathepsin G inhibitory aptamer from a pool of synthetic oligonucleotides", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 353, no. 4, 1996, pages R13, XP002112705, ISSN: 0028-1298
BRACHT ET AL: "Isolation and functional characterization of a specific cathepsin G inhibitory aptamer from a pool of synthetic oligonucleotides", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 353, no. 4, 1996, pages R13, XP002112705, ISSN: 0028-1298
Download PDF:
Previous Patent: LOOK-THROUGH MUTAGENESIS
Next Patent: DISEASE RESISTANT TRANSGENIC NON-HUMAN ANIMALS
Next Patent: DISEASE RESISTANT TRANSGENIC NON-HUMAN ANIMALS