Title:
DNA DAMAGING AGENTS IN COMBINATION WITH TYROSINE KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO1995020960
Kind Code:
A3
Abstract:
The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.
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Inventors:
WEICHSELBAUM RALPH R (US)
KUFE DONALD (US)
KUFE DONALD (US)
Application Number:
PCT/US1995/001540
Publication Date:
September 21, 1995
Filing Date:
February 06, 1995
Export Citation:
Assignee:
ARCH DEV CORP (US)
DANA FARBER CANCER INST INC (US)
WEICHSELBAUM RALPH R (US)
KUFE DONALD (US)
DANA FARBER CANCER INST INC (US)
WEICHSELBAUM RALPH R (US)
KUFE DONALD (US)
International Classes:
A61K31/40; A61K41/00; (IPC1-7): A61K31/35; A61K31/395; A61K31/40; A61K31/405; A61K33/24
Other References:
DATABASE WPI Section Ch Week 9021, Derwent World Patents Index; Class B05, AN 90-161325
WATANABE T ET AL: "INHIBITORS FOR PROTEIN-TYROSINE KINASES, ST638 AND GENISTEIN, INDUCE DIFFERENTIATION OF MOUSE ERYTHROLEUKEMIA CELLS IN A SYNERGISTIC MANNER", EXP CELL RES, VOL. 183, NO. 2, PAGES 335-42
ODUM N ET AL: "Signal transduction by HLA class II molecules in human T cells: induction of LFA-1-dependent and independent adhesion.", HUM IMMUNOL, OCT 1992, VOL. 35, NO. 2, PAGES 71-84, UNITED STATES
DATABASE CANCERLIT NATIONAL CANCER INSTITUTE, US; HALLAHAN D ET AL: "X-RAY INDUCED PROTEIN KINASE C ACTIVATION MEDIATES PROTO-ONCOGENE JUN EXPRESSION (MEETING ABSTRACT)"
DATABASE CANCERLIT NATIONAL CANCER INSTITUTE, US; DARZYNKIEWICZ Z ET AL: "Apoptotic mechanism of cell death during treatment of acute leukemias (Meeting abstract)."
UCKUN F.M. ET AL: "Ionizing radiation stimulates unidentified tyrosine -specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death", PROC. NATL ACAD. SCI. U. S. A., 1992, VOL. 89, NO. 19, PAGE(S) 9005-9009
KHARBANDA S ET AL: "Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation.", J BIOL CHEM, VOL. 269, NO. 32, PAGE(S) 20739-43, 12 August 1994 (1994-08-12)
KHARBANDA S ET AL: "p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.", ONCOGENE, OCT 1994, VOL. 9, NO. 10, PAGES 3005-11
WATANABE T ET AL: "INHIBITORS FOR PROTEIN-TYROSINE KINASES, ST638 AND GENISTEIN, INDUCE DIFFERENTIATION OF MOUSE ERYTHROLEUKEMIA CELLS IN A SYNERGISTIC MANNER", EXP CELL RES, VOL. 183, NO. 2, PAGES 335-42
ODUM N ET AL: "Signal transduction by HLA class II molecules in human T cells: induction of LFA-1-dependent and independent adhesion.", HUM IMMUNOL, OCT 1992, VOL. 35, NO. 2, PAGES 71-84, UNITED STATES
DATABASE CANCERLIT NATIONAL CANCER INSTITUTE, US; HALLAHAN D ET AL: "X-RAY INDUCED PROTEIN KINASE C ACTIVATION MEDIATES PROTO-ONCOGENE JUN EXPRESSION (MEETING ABSTRACT)"
DATABASE CANCERLIT NATIONAL CANCER INSTITUTE, US; DARZYNKIEWICZ Z ET AL: "Apoptotic mechanism of cell death during treatment of acute leukemias (Meeting abstract)."
UCKUN F.M. ET AL: "Ionizing radiation stimulates unidentified tyrosine -specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death", PROC. NATL ACAD. SCI. U. S. A., 1992, VOL. 89, NO. 19, PAGE(S) 9005-9009
KHARBANDA S ET AL: "Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation.", J BIOL CHEM, VOL. 269, NO. 32, PAGE(S) 20739-43, 12 August 1994 (1994-08-12)
KHARBANDA S ET AL: "p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.", ONCOGENE, OCT 1994, VOL. 9, NO. 10, PAGES 3005-11
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