Title:
DNA ENCODING PROTEIN KINASE
Document Type and Number:
WIPO Patent Application WO/1996/028554
Kind Code:
A1
Abstract:
Cloning of a cDNA of a novel protein kinase which is assumed to play various roles in vivo. A DNA containing a base sequence which encodes an amino acid sequence encoding a novel protein kinase, a base sequence which is the same as the above-mentioned one except having partial insertion, deletion or replacement, or a base sequence hybridizable therewith; a plasmid having this DNA; a transformant having this plasmid; a process for producing the DNA; and an oligonucleotide hybridizable specifically with the base sequence encoding the above-mentioned amino acid sequence.
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Inventors:
NEZU JUNICHI (JP)
Application Number:
PCT/JP1996/000660
Publication Date:
September 19, 1996
Filing Date:
March 15, 1996
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
NEZU JUNICHI (JP)
NEZU JUNICHI (JP)
International Classes:
C12N1/21; C12N9/12; C12N15/12; C12N15/54; (IPC1-7): C12N15/54; C12N9/10
Other References:
PROC. NATL. ACAD. SCI. U.S.A., Vol. 84, (1987), STEVEN K. HANDS et al., "Homology Probing: Identification of cDNA Clones Encoding Members of the Protein-Serine Kinase Family", pages 388-392.
ONCOGENE, Vol. 9, No. 12, (1994), LARSSON CATHARINA et al., "BMX, A Novel Nonreceptor Tyrosine Kinase Gene of the BTK:ITK:TEC:TXK Family Located in Chromosome Xp22.2", pages 3683-3688.
J. BIOL. CHEM., Vol. 269, No. 14, (1994), MARK MELANIE R. et al., "rse, A Novel Receptor-Type Tyrosine Kinase with Homology to Ax1/Ufo, is Expressed at High Levels in the Brain", pages 10720-10728.
ONCOGENE, Vol. 9, No. 3, (1993), OHASHI KAZUMA et al., "Cloning of the cDNA for a Novel Receptor Tyrosine Kinase, Sky, Predominantly Expressed in Brain", pages 699-705.
ONCOGENE, Vol. 8, No. 12, (1993), KARN THOMAS et al., "Structure, Expression and Chromosomal Mapping of TKT from Man and Mouse: A New Subclass of Receptor Tyrosine Kinase with a Factor VIII-Like Domain", pages 3433-3440.
SCIENCE, Vol. 241, (1988), STEVEN K. HANKS et al., "The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalitic Domains", pages 42-52.
ONCOGENE, Vol. 9, No. 12, (1994), LARSSON CATHARINA et al., "BMX, A Novel Nonreceptor Tyrosine Kinase Gene of the BTK:ITK:TEC:TXK Family Located in Chromosome Xp22.2", pages 3683-3688.
J. BIOL. CHEM., Vol. 269, No. 14, (1994), MARK MELANIE R. et al., "rse, A Novel Receptor-Type Tyrosine Kinase with Homology to Ax1/Ufo, is Expressed at High Levels in the Brain", pages 10720-10728.
ONCOGENE, Vol. 9, No. 3, (1993), OHASHI KAZUMA et al., "Cloning of the cDNA for a Novel Receptor Tyrosine Kinase, Sky, Predominantly Expressed in Brain", pages 699-705.
ONCOGENE, Vol. 8, No. 12, (1993), KARN THOMAS et al., "Structure, Expression and Chromosomal Mapping of TKT from Man and Mouse: A New Subclass of Receptor Tyrosine Kinase with a Factor VIII-Like Domain", pages 3433-3440.
SCIENCE, Vol. 241, (1988), STEVEN K. HANKS et al., "The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalitic Domains", pages 42-52.
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