Title:
DNA METHYLTRANSFERASE
Document Type and Number:
WIPO Patent Application WO/2023/234419
Kind Code:
A1
Abstract:
Provided is, for example, a DNA methyltransferase that can recognize and methylate a short context other than a CG dinucleotide sequence in which endogenous methylation occurs, the short context being comparable to the CG dinucleotide sequence. The present invention pertains to a protein or the like in which some amino acid residues including the N terminal of a DNA methyltransferase of M.CviQIX or M.CviPII have been deleted, and activity of specifically recognizing a CC dinucleotide sequence and 5-methylating a cytosine residue of the 5' side in the sequence is acquired.
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Inventors:
MIURA FUMIHITO (JP)
Application Number:
PCT/JP2023/020732
Publication Date:
December 07, 2023
Filing Date:
May 29, 2023
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
C12N5/10; C12N1/15; C12N1/19; C12N1/21; C12N9/10; C12N15/54; C12N15/63; C12Q1/48; C12Q1/68
Domestic Patent References:
| WO2006047183A2 | 2006-05-04 |
Other References:
ZHANG, Y. NELSON, M. NIETFELDT, J. XIA, Y. BURBANK, D. ROPP, S. VAN ETTEN, J.L.: "Chlorella Virus NY-2A Encodes at Least 12 DNA Endonuclease/Methyltransferase Genes", VIROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 240, no. 2, 15 January 1998 (1998-01-15), AMSTERDAM, NL , pages 366 - 375, XP004457916, ISSN: 0042-6822, DOI: 10.1006/viro.1997.8936
MIURA FUMIHITO, MIURA MIKI, SHIBATA YUKIKO, FURUTA YOSHIKAZU, MIYAMURA KEISUKE, INO YUKI, BAYOUMI ASMAA M. A., OBA UTAKO, ITO TAKA: "Identification, expression, and purification of DNA cytosine 5-methyltransferases with short recognition sequences", BMC BIOTECHNOLOGY, BIOMED CENTRAL LTD, vol. 22, no. 1, XP093115644, ISSN: 1472-6750, DOI: 10.1186/s12896-022-00765-3
MIURA FUMIHITO, MIURA MIKI, SHIBATA YUKIKO, FURUTA YOSHIKAZU, MIYAMURA KEISUKE, INO YUKI, BAYOUMI ASMAA M. A., OBA UTAKO, ITO TAKA: "Identification, expression, and purification of DNA cytosine 5-methyltransferases with short recognition sequences", BMC BIOTECHNOLOGY, BIOMED CENTRAL LTD, vol. 22, no. 1, XP093115644, ISSN: 1472-6750, DOI: 10.1186/s12896-022-00765-3
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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