Title:
A DNA SEQUENCE ENCODING THE MAS ONCOGENE,POLYPEPTIDES ENCODED THEREFROM,AND DIAGNOSTIC AND OTHER METHODS BASED THEREON
Document Type and Number:
WIPO Patent Application WO1987007472
Kind Code:
A3
Abstract:
This invention provides a DNA sequence comprising an activated oncogene, said oncogene encoding a polypeptide capable of transforming NIH3T3 cells and of inducing a tumor when injected into nude mice, said DNA sequence having a nucleotide sequence substantially as shown in FIGS. 3A and 3B. The invention also concerns a polypeptide molecule encoded by an activated oncogene, said molecule having the properties of transforming NIH3T3 cells and of inducing a tumor when injected into nude mice and further said polypeptide having an amino acid sequence substantially as shown in FIGS. 3A and 3B. Finally, this invention provides a method for treating a tumor induced by an activated mas oncogene.
Inventors:
YOUNG DALLAN (US)
WIGLER MICHAEL H (US)
FASANO OTTAVIO (US)
WIGLER MICHAEL H (US)
FASANO OTTAVIO (US)
Application Number:
PCT/US1987/001347
Publication Date:
December 30, 1987
Filing Date:
June 02, 1987
Export Citation:
Assignee:
COLD SPRING HARBOR LAB (US)
International Classes:
G01N33/50; A61K39/00; A61K39/395; C07H21/04; C07K14/00; C07K14/82; C07K16/00; C07K16/32; C12N15/09; C12P21/02; C12Q1/68; G01N33/574; A61K38/00; C12R1/91; (IPC1-7): C12N15/00
Domestic Patent References:
| WO1984003087A1 | 1984-08-16 |
Foreign References:
| US4460559A | 1984-07-17 | |||
| US4535058A | 1985-08-13 | |||
| US4542096A | 1985-09-17 | |||
| EP0108564A1 | 1984-05-16 | |||
| US4559311A | 1985-12-17 | |||
| US4599305A | 1986-07-08 |
Other References:
Proceedings of the National Academy of Sciences, Vol. 80, issued April 1983 (The National Academy of Sciences, Washington, DC 20418), K. SHIMIZU et al, "Three Human Transforming Genes...", pages 2112-2116, see Abstract.
Molecular and Cellular Biology, Vol. 4, No. 9, issued September 1984 (American Society for Microbiology, Washington, DC 20006), O. FASANO et al, "New Human Transforming Genes...", pages 1695-1705, see page 1696, column 1, Lines 5-20.
Journal of Immunological Methods, Vol. 85, issued September 1985 (Elsevier Science Publishers, Amsterdam, The Netherlands), R.H. KENNETT et al, "Detection of E. Coli Colonies...", pages 169-182, see Abstract, page 180, Lines 15-30.
See also references of EP 0272321A4
Molecular and Cellular Biology, Vol. 4, No. 9, issued September 1984 (American Society for Microbiology, Washington, DC 20006), O. FASANO et al, "New Human Transforming Genes...", pages 1695-1705, see page 1696, column 1, Lines 5-20.
Journal of Immunological Methods, Vol. 85, issued September 1985 (Elsevier Science Publishers, Amsterdam, The Netherlands), R.H. KENNETT et al, "Detection of E. Coli Colonies...", pages 169-182, see Abstract, page 180, Lines 15-30.
See also references of EP 0272321A4
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