Title:
DNA TETRAHEDRAL PHARMACEUTICAL COMPLEX FOR TREATING NEOVASCULAR RETINAL DISEASES, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/045250
Kind Code:
A1
Abstract:
A DNA tetrahedral pharmaceutical complex for treating neovascular retinal diseases, which is a complex formed by TDNs carrying Bevasiranib. The complex exhibits an excellent inhibitory effect on neovascularization, significantly improves ocular fundus leakage, and has a very prominent retinal repair effect.
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Inventors:
LUO DELUN (CN)
XU XIAOXIAO (CN)
WU DAYING (CN)
XU XIAOXIAO (CN)
WU DAYING (CN)
Application Number:
PCT/CN2022/121365
Publication Date:
March 07, 2024
Filing Date:
September 26, 2022
Export Citation:
Assignee:
CHENGDU GENREZE GENE TECH CO LTD (CN)
International Classes:
C12N15/11; A61K31/711; A61K31/713; A61P9/10; A61P27/02
Foreign References:
| CN112843085A | 2021-05-28 | |||
| CN112007044A | 2020-12-01 | |||
| CN114404608A | 2022-04-29 | |||
| US20080152654A1 | 2008-06-26 |
Other References:
ZHAO DAN, LIU MENGTING, LI JIAJIE, XIAO DEXUAN, PENG SHUANGLIN, HE QING, SUN YUE, LI QIRONG, LIN YUNFENG: "Angiogenic Aptamer-Modified Tetrahedral Framework Nucleic Acid Promotes Angiogenesis In Vitro and In Vivo", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 25, 30 June 2021 (2021-06-30), US , pages 29439 - 29449, XP093145104, ISSN: 1944-8244, DOI: 10.1021/acsami.1c08565
FU WEI, MA LU, JU YAN, XU JIANGUO, LI HAO, SHI SIRONG, ZHANG TAO, ZHOU RONGHUI, ZHU JIANWEI, XU RUXIANG, YOU CHAO, LIN YUNFENG: "Therapeutic siCCR2 Loaded by Tetrahedral Framework DNA Nanorobotics in Therapy for Intracranial Hemorrhage", ADVANCED FUNCTIONAL MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 31, no. 33, 1 August 2021 (2021-08-01), DE , pages 2101435, XP093145106, ISSN: 1616-301X, DOI: 10.1002/adfm.202101435
WANG SHAOCHUANG, LIU HUI, REN LIFENG, PAN YIFENG, ZHANG YANGDE: "Inhibiting Colorectal Carcinoma Growth and Metastasis By Blocking the Expression of VEGF Using RNA Interference", NEOPLASIA, NEOPLASIA PRESS, US, vol. 10, no. 4, 1 April 2008 (2008-04-01), US , pages 399 - 407, XP093145105, ISSN: 1476-5586, DOI: 10.1593/neo.07613
FU WEI, MA LU, JU YAN, XU JIANGUO, LI HAO, SHI SIRONG, ZHANG TAO, ZHOU RONGHUI, ZHU JIANWEI, XU RUXIANG, YOU CHAO, LIN YUNFENG: "Therapeutic siCCR2 Loaded by Tetrahedral Framework DNA Nanorobotics in Therapy for Intracranial Hemorrhage", ADVANCED FUNCTIONAL MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 31, no. 33, 1 August 2021 (2021-08-01), DE , pages 2101435, XP093145106, ISSN: 1616-301X, DOI: 10.1002/adfm.202101435
WANG SHAOCHUANG, LIU HUI, REN LIFENG, PAN YIFENG, ZHANG YANGDE: "Inhibiting Colorectal Carcinoma Growth and Metastasis By Blocking the Expression of VEGF Using RNA Interference", NEOPLASIA, NEOPLASIA PRESS, US, vol. 10, no. 4, 1 April 2008 (2008-04-01), US , pages 399 - 407, XP093145105, ISSN: 1476-5586, DOI: 10.1593/neo.07613
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (CN)
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