Title:
DNA VACCINE COMPOSITION COMPRISING HEPATITIS VIRUS B-DERIVED MUTANT MOLECULE AND PATHOGEN- OR TUMOR-ASSOCIATED ANTIGEN MOLECULE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/146125
Kind Code:
A1
Abstract:
The present invention relates to a DNA vaccine composition comprising a hepatitis virus B-derived mutant molecule and an antigen molecule of a pathogen or a tumor-associated antigen protein, and a use thereof as a prophylactic or therapeutic composition for pathogen infection or tumor. Including the hepatitis virus B-derived mutant molecule therein, a vaccine composition according to an aspect exhibits a remarkable effect of activating humoral immunity and cellular immunity, compared to conventional DNA vaccines and as such, can be advantageously used as a prophylactic or therapeutic vaccine for pathogenic infections, for example, viral infections or bacterial infections or tumors.
Inventors:
KIM BYOUNG JUN (KR)
KIM BUM JOON (KR)
CHOI YU MIN (KR)
JEONG HYE IN (KR)
KIM BUM JOON (KR)
CHOI YU MIN (KR)
JEONG HYE IN (KR)
Application Number:
PCT/KR2022/000053
Publication Date:
July 07, 2022
Filing Date:
January 04, 2022
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07K14/005; A23L33/18; A61K38/00; A61K39/12; A61P31/12; C07K14/35; C12N15/62
Foreign References:
| KR101382734B1 | 2014-04-08 |
Other References:
JUNWU LI, JUNYUAN GONG, XIN LIU, QIUPING YE, DONG SONG, RENJIE XIAO: "Construction of a fusion gene containing hepatitis B virus L gene and Mycobacterium tuberculosis Ag85B gene and its expression in Pichia pastoris", AFRICAN JOURNAL OF BIOTECHNOLOGY, vol. 10, no. 60, pages 12840 - 12846, XP055947295, DOI: 10.5897/AJB11.190
DATABASE PROTEIN 13 July 2005 (2005-07-13), ANONYMOUS : "preS1/S2/S [Hepatitis B virus]", XP055947297, retrieved from NCBI Database accession no. AAZ05273
YANG Z., ET AL.: "Stable and efficient expression of hepatitis B virus S antigen and preS1 epitope fusion protein (S/preS1) in CHO cells", CHINESE JOURNAL OF BIOTECHNOLOGY, vol. 29, no. 12, 25 December 2013 (2013-12-25), pages 1808 - 1816, XP055947302, DOI: 10.13345/j.cjb.2013.12.011
HOSSAIN MD. GOLZAR, MAHMUD MD. MUKET, NAZIR K. H. M. NAZMUL HUSSAIN, UEDA KEIJI: "PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 2, 15 January 2020 (2020-01-15), pages 546, XP055947303, DOI: 10.3390/ijms21020546
JEONG HYEIN, CHOI YU-MIN, SEO HYEJUN, KIM BUM-JOON: "A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P Mutation", FRONTIERS IN IMMUNOLOGY, vol. 12, 26 February 2021 (2021-02-26), pages 637654, XP055843260, DOI: 10.3389/fimmu.2021.637654
DATABASE PROTEIN 13 July 2005 (2005-07-13), ANONYMOUS : "preS1/S2/S [Hepatitis B virus]", XP055947297, retrieved from NCBI Database accession no. AAZ05273
YANG Z., ET AL.: "Stable and efficient expression of hepatitis B virus S antigen and preS1 epitope fusion protein (S/preS1) in CHO cells", CHINESE JOURNAL OF BIOTECHNOLOGY, vol. 29, no. 12, 25 December 2013 (2013-12-25), pages 1808 - 1816, XP055947302, DOI: 10.13345/j.cjb.2013.12.011
HOSSAIN MD. GOLZAR, MAHMUD MD. MUKET, NAZIR K. H. M. NAZMUL HUSSAIN, UEDA KEIJI: "PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 2, 15 January 2020 (2020-01-15), pages 546, XP055947303, DOI: 10.3390/ijms21020546
JEONG HYEIN, CHOI YU-MIN, SEO HYEJUN, KIM BUM-JOON: "A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P Mutation", FRONTIERS IN IMMUNOLOGY, vol. 12, 26 February 2021 (2021-02-26), pages 637654, XP055843260, DOI: 10.3389/fimmu.2021.637654
Attorney, Agent or Firm:
THEWAVE IP LAW FIRM (KR)
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