Title:
DNP-NMR POLARIZING AGENT, METHOD FOR MANUFACTURING SAME, AND METHOD FOR USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/027047
Kind Code:
A1
Abstract:
Provided are polarizing agent with which it is possible to selectively enhance an NMR signal by using a DNP-NMR method even in a reductive environment, and a method for selectively enhancing an NMR signal. The present invention is a polarizing agent used in a DNP-NMR method, the polarizing agent containing nanodiamond particles, and the surfaces of the nanodiamond particles being modified using a functional group capable of covalently bonding with or interacting with proteins. This polarizing agent makes it possible to selectively enhance an NMR signal by using a DNP-NMR method even in a reductive environment.
Inventors:
MATSUKI YOH (JP)
KATO KEN (JP)
FUJIWARA TOSHIMICHI (JP)
KATO KEN (JP)
FUJIWARA TOSHIMICHI (JP)
Application Number:
PCT/JP2022/031633
Publication Date:
March 02, 2023
Filing Date:
August 22, 2022
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
G01N24/08
Foreign References:
| US20210179581A1 | 2021-06-17 | |||
| JP2018514795A | 2018-06-07 | |||
| US20180113185A1 | 2018-04-26 |
Other References:
CHRISTIAN O. BRETSCHNEIDER; ÜMIT AKBEY; FABIEN AUSSENAC; GREG L. OLSEN; AKIVA FEINTUCH; HARTMUT OSCHKINAT; LUCIO FRYDMAN: "On The Potential of Dynamic Nuclear Polarization Enhanced Diamonds in Solid‐State and Dissolution 13C NMR Spectroscopy", CHEMPHYSCHEM, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 17, no. 17, 15 July 2016 (2016-07-15), DE , pages 2691 - 2701, XP072154929, ISSN: 1439-4235, DOI: 10.1002/cphc.201600301
VADYM N. MOCHALIN, OLGA SHENDEROVA, DEAN HO, YURY GOGOTSI: "The properties and applications of nanodiamonds", NATURE NANOTECHNOLOGY, NATURE PUB. GROUP, INC., vol. 7, no. 1, pages 11 - 23, XP055133599, ISSN: 17483387, DOI: 10.1038/nnano.2011.209
RANKIN ANDREW G.M.; TRÉBOSC JULIEN; POURPOINT FRÉDÉRIQUE; AMOUREUX JEAN-PAUL; LAFON OLIVIER: "Recent developments in MAS DNP-NMR of materials", SOLID STATE NUCLEAR MAGNETIC RESONANCE, ELSEVIER, AMSTERDAM, NL, vol. 101, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 116 - 143, XP085721069, ISSN: 0926-2040, DOI: 10.1016/j.ssnmr.2019.05.009
LIAO WEI-CHIH, ONG TA-CHUNG, GAJAN DAVID, BERNADA FLORIAN, SAUVÉE CLAIRE, YULIKOV MAXIM, PUCINO MARGHERITA, SCHOWNER ROMAN, SCHWAR: "Dendritic polarizing agents for DNP SENS", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 8, no. 1, 1 January 2017 (2017-01-01), United Kingdom , pages 416 - 422, XP093039031, ISSN: 2041-6520, DOI: 10.1039/C6SC03139K
MOROZ ILIA B, LESKES MICHAL: "Dynamic Nuclear Polarization Solid-State NMR Spectroscopy for Materials Research", ANNUAL REVIEW OF MATERIALS RESEARCH, vol. 52, 8 March 2022 (2022-03-08), pages 25 - 55, XP093039029, DOI: 10.1146/annurev-matsci-081720-
T. VIENNETA. VIEGASA. KUEPPERS. ARENSV. GELEVO. PETROVT.N. GROSSMANNH. HEISEM. ETZKORN, ANGEW. CHEM. INT. ED, vol. 55, 2016, pages 10746 - 10750
VADYM N. MOCHALIN, OLGA SHENDEROVA, DEAN HO, YURY GOGOTSI: "The properties and applications of nanodiamonds", NATURE NANOTECHNOLOGY, NATURE PUB. GROUP, INC., vol. 7, no. 1, pages 11 - 23, XP055133599, ISSN: 17483387, DOI: 10.1038/nnano.2011.209
RANKIN ANDREW G.M.; TRÉBOSC JULIEN; POURPOINT FRÉDÉRIQUE; AMOUREUX JEAN-PAUL; LAFON OLIVIER: "Recent developments in MAS DNP-NMR of materials", SOLID STATE NUCLEAR MAGNETIC RESONANCE, ELSEVIER, AMSTERDAM, NL, vol. 101, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 116 - 143, XP085721069, ISSN: 0926-2040, DOI: 10.1016/j.ssnmr.2019.05.009
LIAO WEI-CHIH, ONG TA-CHUNG, GAJAN DAVID, BERNADA FLORIAN, SAUVÉE CLAIRE, YULIKOV MAXIM, PUCINO MARGHERITA, SCHOWNER ROMAN, SCHWAR: "Dendritic polarizing agents for DNP SENS", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 8, no. 1, 1 January 2017 (2017-01-01), United Kingdom , pages 416 - 422, XP093039031, ISSN: 2041-6520, DOI: 10.1039/C6SC03139K
MOROZ ILIA B, LESKES MICHAL: "Dynamic Nuclear Polarization Solid-State NMR Spectroscopy for Materials Research", ANNUAL REVIEW OF MATERIALS RESEARCH, vol. 52, 8 March 2022 (2022-03-08), pages 25 - 55, XP093039029, DOI: 10.1146/annurev-matsci-081720-
T. VIENNETA. VIEGASA. KUEPPERS. ARENSV. GELEVO. PETROVT.N. GROSSMANNH. HEISEM. ETZKORN, ANGEW. CHEM. INT. ED, vol. 55, 2016, pages 10746 - 10750
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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