Title:
DOPAMINE-PRODUCING NEURON PROGENITOR CELL MARKER 187A5
Document Type and Number:
WIPO Patent Application WO/2007/119759
Kind Code:
A1
Abstract:
The object is to provide a probe, a primer, a primer set or an antibody which can be used for the detection or screening of a dopamine-producing neuron progenitor cell. Disclosed is a probe, a primer or a primer set capable of hybridizing with the nucleotide sequence of 187A5 gene or a complementary sequence thereof, which can be used for the detection or screening of a midbrain dopamine-producing neuron progenitor cell, preferably a dopamine-producing neuron proliferation progenitor cell. Also disclosed is an antibody capable of binding to 187A5 protein, which can be used for the detection or screening of a midbrain dopamine-producing neuron progenitor cell, preferably a dopamine-producing neuron progenitor cell.
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Inventors:
ONO YUICHI (JP)
SAKAMOTO YOSHIMASA (JP)
SAKAMOTO YOSHIMASA (JP)
Application Number:
PCT/JP2007/058009
Publication Date:
October 25, 2007
Filing Date:
April 11, 2007
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
ONO YUICHI (JP)
SAKAMOTO YOSHIMASA (JP)
ONO YUICHI (JP)
SAKAMOTO YOSHIMASA (JP)
International Classes:
C12N15/09; A61K35/30; A61P25/16; C07K14/47; C07K16/18; C12N5/10; C12Q1/02; C12Q1/04; C12Q1/68; C12Q1/6881; G01N33/53
Domestic Patent References:
| WO2004094651A2 | 2004-11-04 | |||
| WO2004094598A2 | 2004-11-04 | |||
| WO2004048938A2 | 2004-06-10 | |||
| WO2007021004A1 | 2007-02-22 | |||
| WO2007021003A1 | 2007-02-22 | |||
| WO2006009241A1 | 2006-01-26 | |||
| WO2005052190A1 | 2005-06-09 | |||
| WO2004065599A1 | 2004-08-05 | |||
| WO2004038018A1 | 2004-05-06 | |||
| WO2004065599A1 | 2004-08-05 | |||
| WO2004038018A1 | 2004-05-06 | |||
| WO2004052190A1 | 2004-06-24 | |||
| WO2000028082A1 | 2000-05-18 | |||
| WO2007021003A1 | 2007-02-22 | |||
| WO2007021004A1 | 2007-02-22 | |||
| WO2005052190A1 | 2005-06-09 |
Foreign References:
| EP1447413A2 | 2004-08-18 | |||
| US5690927A | 1997-11-25 | |||
| JPH10508487A | 1998-08-25 | |||
| JPH10508488A | 1998-08-25 | |||
| JPH10509034A | 1998-09-08 | |||
| JPH11509170A | 1999-08-17 | |||
| JPH11501818A | 1999-02-16 | |||
| JPH08509215A | 1996-10-01 | |||
| JPH11506930A | 1999-06-22 | |||
| JP2002522070A | 2002-07-23 | |||
| JPH09505054A | 1997-05-20 | |||
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| JP2002051775A | 2002-02-19 | |||
| JPS60500684A | 1985-05-09 |
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LEE ET AL., NAT. BIOTECH., vol. 18, 2000, pages 675 - 679
See also references of EP 2006382A4
SPENCER ET AL., N. ENGL. J. MED., vol. 327, 1992, pages 1541 - 8
FREED ET AL., N. ENGL. J. MED., vol. 327, 1992, pages 1549 - 55
WIDNER ET AL., N. ENGL. J. MED., vol. 327, 1992, pages 1556 - 63
KORDOWER ET AL., N. ENGL. J. MED., vol. 332, 1995, pages 1118 - 24
DEFER ET AL., BRAIN, vol. 119, 1996, pages 41 - 50
LOPEZ-LOZANO ET AL., TRANSP. PROC., vol. 29, 1997, pages 977 - 80
ROSENSTAIN, EXP. NEUROL., vol. 33, 1995, pages 106
TURNER ET AL., NEUROSURG., vol. 33, 1993, pages 1031 - 7
BRUDIN, BRAIN RES. REV., vol. 13, 1988, pages 287 - 324
ROSENSTEIN, EXP. NEUROL., vol. 33, 1995, pages 106
SELAWLY; CAMERON, CELL TRANSPLANT, vol. 2, 1993, pages 123 - 9
KIM ET AL., NATURE, vol. 418, 2002, pages 50 - 56
LINDVALL ET AL., ARCH. NEUROL., vol. 46, 1989, pages 615 - 31
WILBUR, NATL. ACAD. SCI. U.S.A., vol. 80, 1983, pages 726 - 730
ALTSCHUL, J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
PEASRON, METHODS IN ENZYMOLOGY, vol. 183, 1990, pages 63 - 69
"Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR PRESS
"Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
MARK ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 5662 - 6
ZOLLER; SMITH, NUCLEIC ACIDS RES., vol. 10, 1982, pages 6487 - 500
WANG ET AL., SCIENCE, vol. 224, 1984, pages 1431 - 3
DALBADIE-MCFARLAND ET AL., PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409 - 13
HASHIMOTO-GOTO ET AL., GENE, vol. 152, 1995, pages 271 - 5
KINKEL, PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488 - 92
KRAMER; FRITZ, METHOD. ENZYMOL, vol. 154, 1987, pages 350 - 67
KUNKEL, METHOD. ENZYMOL., vol. 85, 1988, pages 2763 - 6
KYTE-DOOLITTLE, J. MOL. BIOL., vol. 157, 1982, pages 105 - 22
CHOU-FASMAN, ANN. REV. BIOCHEM., vol. 47, 1978, pages 251 - 76
ANAL. BIOCHEM., vol. 151, 1985, pages 540 - 6
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
NATURE, vol. 256, 1975, pages 495
STUDER, L. ET AL., NATURE NEUROSCI, vol. 1, 1998, pages 290 - 295
KAWASAKI ET AL., NEURON, vol. 28, no. 1, 2000, pages 31 - 40
LEE, SH. ET AL., NATURE BIOTECH, vol. 18, 2000, pages 675 - 579
KAWASAKI, NEURON, vol. 28, no. 1, 2000, pages 31 - 40
"DNA Cloning 1: Core Techniques, A Practical Approach", 1995
KELE J ET AL.: "Neurogenin 2 is required for the development of ventral mesencephalon dopaminergic neurons", DEVELOPMENT, vol. 133, no. 3, February 2006 (2006-02-01), pages 495 - 505
SCIENCE, vol. 276, no. 5310, November 1997 (1997-11-01), pages 248 - 50
J. NEUROSCI., vol. 21, no. 9, 2001, pages 3126 - 34
PROC. NATL. ACAD. SCI., vol. 94, 1997, pages 13305 - 10
DEVELOPMENT, vol. 131, 2003, pages 1145 - 55
KAWASAKI ET AL., NEURON, vol. 28, no. 1, October 2000 (2000-10-01), pages 31 - 40
LEE ET AL., NAT. BIOTECH., vol. 18, 2000, pages 675 - 679
See also references of EP 2006382A4
Attorney, Agent or Firm:
YOSHITAKE, Kenji et al. (Room 323 Fuji Bldg., 2-3,Marunouchi 3-chome, Chiyoda-ku Tokyo 05, JP)
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