Title:
DOUBLE NETWORKED 3D-PRINTED BIOMATERIALS
Document Type and Number:
WIPO Patent Application WO/2024/026023
Kind Code:
A3
Abstract:
A 3D-printed biomaterial is described that comprises a double-networked hydrogel comprising gelatin or gelatin methacryloyl and alginate, and cells. Methods of making the 3D-printed biomaterial by extruding a hydrogel comprising gelatin or gelatin methacryloyl and alginate from a 3D-printer and converting the hydrogel to a double-networked hydrogel by cross-linking the gelatin with a first cross-linking method and cross-linking the alginate with a second cross-linking method are also described. Methods of treating a damaged or diseased blood vessel and testing vasoactive drugs using 3D-printed blood vessels are also described.
Inventors:
ZHANG YU SHRIKE (US)
KUANG XIAO (US)
KUANG XIAO (US)
Application Number:
PCT/US2023/028853
Publication Date:
March 07, 2024
Filing Date:
July 27, 2023
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL INC (US)
International Classes:
A61L26/00; A61L27/14; A61L27/18; A61L27/38; A61L27/50; C12N5/07
Domestic Patent References:
| WO2018053404A1 | 2018-03-22 | |||
| WO2022225458A1 | 2022-10-27 |
Foreign References:
| US11339361B2 | 2022-05-24 | |||
| US20200164109A1 | 2020-05-28 |
Attorney, Agent or Firm:
WESORICK, Richard S. (US)
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