Title:
DRUG CONJUGATE OF ERIBULIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2021/148003
Kind Code:
A1
Abstract:
The present disclosure relates to a drug conjugate of an Eribulin derivative, a preparation method therefor and an application thereof in medicine. Specifically, provided is an antibody-drug conjugate, which contains an Eribulin derivative drug portion. The present disclosure further relates to a method for treating cancer by administering the antibody-drug conjugate provided herein.
Inventors:
HUANG JIAN (CN)
ZHU LINGJIAN (CN)
YU XIUZHAO (CN)
ZHU BO (CN)
REN WENMING (CN)
TANG MI (CN)
SUN XING (CN)
YANG YANG (CN)
LIANG JINDONG (CN)
HU QIYUE (CN)
ZHU LINGJIAN (CN)
YU XIUZHAO (CN)
ZHU BO (CN)
REN WENMING (CN)
TANG MI (CN)
SUN XING (CN)
YANG YANG (CN)
LIANG JINDONG (CN)
HU QIYUE (CN)
Application Number:
PCT/CN2021/073314
Publication Date:
July 29, 2021
Filing Date:
January 22, 2021
Export Citation:
Assignee:
SHANGHAI SENHUI MEDICINE CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
A61K47/68; A61P35/00; C07D307/20; C07K16/28
Domestic Patent References:
| WO2019114666A1 | 2019-06-20 | |||
| WO2018217894A1 | 2018-11-29 | |||
| WO2004010957A2 | 2004-02-05 | |||
| WO2005001038A2 | 2005-01-06 | |||
| WO2008025020A2 | 2008-02-28 | |||
| WO2005037992A2 | 2005-04-28 | |||
| WO2020063676A1 | 2020-04-02 | |||
| WO2003074566A2 | 2003-09-12 | |||
| WO2017151979A1 | 2017-09-08 | |||
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Other References:
CHENG XIN, LI JING, TANAKA KEIGO, MAJUMDER UTPAL, MILINICHIK ANDREW Z., VERDI ARIELLE C., MADDAGE CHRISTOPHER J., RYBINSKI KATHERI: "MORAb-202, an Antibody–Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH [, US, vol. 17, no. 12, 1 December 2018 (2018-12-01), US, pages 2665 - 2675, XP055831595, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-17-1215
MULLARD A, NATURE REVIEWS DRUG DISCOVERY, vol. 12, 2013, pages 329 - 332
DIJOSEPH JFARMELLINO DC, BLOOD, vol. 103, 2004, pages 1807 - 1814
DRUGS OF THE FUTURE, vol. 25, no. 7, 2000, pages 686
NAT. BIOTECHNOL, vol. 21, no. 7, 2003, pages 778 - 784
MUKHTAR ET AL., MOL.CANCER THER, vol. 13, 2014, pages 275 - 84
DUMONTETJORDAN, NAT.REV.DRUG DISCOV, vol. 9, 2010, pages 790 - 803
CHARI ET AL., CANCER RESEARCH, vol. 52, 1992, pages 127 - 131
J. BIOL. CHEM, vol. 243, 1968, pages 3558
CHINESE PHARMACOPOEIA, vol. 0542, 2015
QUEEN ET AL., PROC., NATL.ACAD.SCI. USA, vol. 88, 1991, pages 2869
JONES ET AL., NATURE, vol. 321, 1986, pages 522
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
VERHOEYEN ET AL., SCIENCE, vol. 242, 1988, pages 1534 - 426
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG, vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES., vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL, 2001
KABAT E.A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE
AL-LAZIKANI ET AL., JMB, vol. 273, 1997, pages 927 - 948
LEFRANC M.P., IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC, M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
Greene Publishing Association, Wiley Interscience; "NCBI", Database accession no. NP_000617.1
BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 5551 - 5554
BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 5551 - 5554
BIOORG. MED. CHEM. LETT., vol. 21, 2011, pages 1639 - 1643
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, 2004, pages 5551 - 5554
See also references of EP 4094779A4
MULLARD A, NATURE REVIEWS DRUG DISCOVERY, vol. 12, 2013, pages 329 - 332
DIJOSEPH JFARMELLINO DC, BLOOD, vol. 103, 2004, pages 1807 - 1814
DRUGS OF THE FUTURE, vol. 25, no. 7, 2000, pages 686
NAT. BIOTECHNOL, vol. 21, no. 7, 2003, pages 778 - 784
MUKHTAR ET AL., MOL.CANCER THER, vol. 13, 2014, pages 275 - 84
DUMONTETJORDAN, NAT.REV.DRUG DISCOV, vol. 9, 2010, pages 790 - 803
CHARI ET AL., CANCER RESEARCH, vol. 52, 1992, pages 127 - 131
J. BIOL. CHEM, vol. 243, 1968, pages 3558
CHINESE PHARMACOPOEIA, vol. 0542, 2015
QUEEN ET AL., PROC., NATL.ACAD.SCI. USA, vol. 88, 1991, pages 2869
JONES ET AL., NATURE, vol. 321, 1986, pages 522
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
VERHOEYEN ET AL., SCIENCE, vol. 242, 1988, pages 1534 - 426
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG, vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES., vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL, 2001
KABAT E.A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE
AL-LAZIKANI ET AL., JMB, vol. 273, 1997, pages 927 - 948
LEFRANC M.P., IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC, M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
Greene Publishing Association, Wiley Interscience; "NCBI", Database accession no. NP_000617.1
BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 5551 - 5554
BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 5551 - 5554
BIOORG. MED. CHEM. LETT., vol. 21, 2011, pages 1639 - 1643
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, 2004, pages 5551 - 5554
See also references of EP 4094779A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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