Title:
DRUG CONJUGATE OF ERIBULIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/001300
Kind Code:
A1
Abstract:
A drug conjugate of an Eribulin derivative. Specifically, provided are an HER2 antibody conjugate that is formed by binding the Eribulin derivative to structural domain II of HER2, a preparation method therefor, and a pharmaceutical application thereof. The present invention further relates to a method for treating a cancer by means of administration of an antibody-drug conjugate, and a composition.
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Inventors:
SUN XING (CN)
YANG CHANGYONG (CN)
LIANG JINDONG (CN)
LIAO CHENG (CN)
YANG CHANGYONG (CN)
LIANG JINDONG (CN)
LIAO CHENG (CN)
Application Number:
PCT/CN2022/107479
Publication Date:
January 26, 2023
Filing Date:
July 22, 2022
Export Citation:
Assignee:
SHANGHAI SENHUI MEDICINE CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K47/68; A61K31/357; A61K39/395; A61P35/00; C07K16/28
Domestic Patent References:
| WO2022022508A1 | 2022-02-03 | |||
| WO2021090062A1 | 2021-05-14 | |||
| WO2021132166A1 | 2021-07-01 | |||
| WO2006033700A2 | 2006-03-30 | |||
| WO2017151979A1 | 2017-09-08 | |||
| WO2013106717A1 | 2013-07-18 |
Foreign References:
| CN108883198A | 2018-11-23 | |||
| CN1312804A | 2001-09-12 | |||
| US20050238649A1 | 2005-10-27 | |||
| US5208020A | 1993-05-04 | |||
| CN201010236637A | 2005-06-03 |
Other References:
CHENG XIN, LI JING, TANAKA KEIGO, MAJUMDER UTPAL, MILINICHIK ANDREW Z., VERDI ARIELLE C., MADDAGE CHRISTOPHER J., RYBINSKI KATHERI: "MORAb-202, an Antibody–Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 17, no. 12, 1 December 2018 (2018-12-01), US , pages 2665 - 2675, XP055831595, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-17-1215
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ALFTHAN ET AL., PROTEIN ENG, vol. 8, 1995, pages 725 - 731
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KIPRIYANOV, J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL., 2001
KABAT E.A. ET AL.: "NIH Publication 91-3242", 1991, article "Sequences of proteins of immunological interest"
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
AL-LAZIKANI ET AL., JMB, vol. 273, 1997, pages 927 - 948
LEFRANC M.P., IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC, M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
"Methods in Molecular Biology", vol. 66, 1996, article "Epitope Mapping Protocols"
IMMUNOGLOBULIN JOURNAL, 2001, ISBN: 012441351
FRANKLIN ET AL., CANCER CELL, vol. 5, 2004, pages 317 - 328
CHARI ET AL., CANCER RESEARCH, vol. 52, 1992, pages 127 - 131
J. BIOL. CHEM, vol. 243, 1968, pages 3558
QUEEN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 2869
JONES ET AL., NATURE, vol. 321, 1986, pages 522
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
VERHOEYEN ET AL., SCIENCE, vol. 242, 1988, pages 1534 - 426
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG, vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES, vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV, J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL., 2001
KABAT E.A. ET AL.: "NIH Publication 91-3242", 1991, article "Sequences of proteins of immunological interest"
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
AL-LAZIKANI ET AL., JMB, vol. 273, 1997, pages 927 - 948
LEFRANC M.P., IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC, M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
"Methods in Molecular Biology", vol. 66, 1996, article "Epitope Mapping Protocols"
IMMUNOGLOBULIN JOURNAL, 2001, ISBN: 012441351
FRANKLIN ET AL., CANCER CELL, vol. 5, 2004, pages 317 - 328
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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