Title:
DRUG CONJUGATE OF GLUCOCORTICOID
Document Type and Number:
WIPO Patent Application WO/2023/143351
Kind Code:
A1
Abstract:
Disclosed is an antibody-drug conjugate represented by formula (I), wherein Ab is an antibody or an antigen-binding fragment thereof, L is a linker covalently linking Ab to D, k is 1 to 20, and D is a glucocorticoid or a residue thereof, the glucocorticoid being selected from budesonide and ciclesonide. Ab-(L-D)k (I)
Inventors:
REN WENMING (CN)
ZHU LINGJIAN (CN)
CHEN HAO (CN)
TANG MANPING (CN)
LIN YUAN (CN)
ZHOU CAIHONG (CN)
HUANG JIAN (CN)
LIAO CHENG (CN)
ZHU LINGJIAN (CN)
CHEN HAO (CN)
TANG MANPING (CN)
LIN YUAN (CN)
ZHOU CAIHONG (CN)
HUANG JIAN (CN)
LIAO CHENG (CN)
Application Number:
PCT/CN2023/073057
Publication Date:
August 03, 2023
Filing Date:
January 19, 2023
Export Citation:
Assignee:
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
SHANGHAI SENHUI MEDICINE CO LTD (CN)
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI SENHUI MEDICINE CO LTD (CN)
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K47/68; A61K31/58; A61P37/00; C07K16/22
Domestic Patent References:
| WO2021148003A1 | 2021-07-29 | |||
| WO2020038454A1 | 2020-02-27 |
Foreign References:
| TW202245796A | 2022-12-01 | |||
| CN113905767A | 2022-01-07 | |||
| CN109476699A | 2019-03-15 | |||
| US20150056221A1 | 2015-02-26 | |||
| US20190167804A1 | 2019-06-06 | |||
| US20200164085A1 | 2020-05-28 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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