Title:
DRUG FOR PREVENTING AND/OR TREATING DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2016/136727
Kind Code:
A1
Abstract:
A drug for preventing and/or treating dementia comprising as an active ingredient a compound represented by formula (I) that has a xanthine oxidase inhibitory effect.
Inventors:
NISHINO TAKESHI (JP)
KATO SHINSUKE (JP)
KATO MASAKO (JP)
SUZUKI HIDENORI (JP)
OKAMOTO KEN (JP)
KATO SHINSUKE (JP)
KATO MASAKO (JP)
SUZUKI HIDENORI (JP)
OKAMOTO KEN (JP)
Application Number:
PCT/JP2016/055226
Publication Date:
September 01, 2016
Filing Date:
February 23, 2016
Export Citation:
Assignee:
NAT UNIV CORP TOTTORI UNIV (JP)
NIPPON MEDICAL SCHOOL FOUNDATION (JP)
NIPPON CHEMIPHAR CO (JP)
NIPPON MEDICAL SCHOOL FOUNDATION (JP)
NIPPON CHEMIPHAR CO (JP)
International Classes:
A61K31/519; A61P25/28
Domestic Patent References:
| WO2005121153A1 | 2005-12-22 |
Foreign References:
| JP2008510827A | 2008-04-10 | |||
| JP2010536811A | 2010-12-02 | |||
| JP2012502966A | 2012-02-02 |
Other References:
VON DEUTSCH , DANIEL A ET AL.: "Is Xanthine Oxidase a Factor in Alzheimer's Dementia?", FASEB JOURNAL, vol. 18, no. 4-5, 2004, pages A933, 617.6, XP009505710
HUANG, X. ET AL.: "Effects of oxidative stress- mediated cell death on A production", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 2, 2001, pages 1521, XP009505708
SHIROLE, T. ET AL.: "4-Methylesculetin a dual acting inhibitor of acetylcholinest erase and xanthine oxidase", CLINICAL THERAPEUTICS, vol. 35, no. 8, 2013, pages e100
ALPAN, AYSE SELCEN ET AL.: "Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 17, 2013, pages 4928 - 4937, XP028690184
HUANG, X. ET AL.: "Effects of oxidative stress- mediated cell death on A production", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 2, 2001, pages 1521, XP009505708
SHIROLE, T. ET AL.: "4-Methylesculetin a dual acting inhibitor of acetylcholinest erase and xanthine oxidase", CLINICAL THERAPEUTICS, vol. 35, no. 8, 2013, pages e100
ALPAN, AYSE SELCEN ET AL.: "Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 17, 2013, pages 4928 - 4937, XP028690184
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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