Title:
DRUG FOR PREVENTING AND/OR TREATING DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2017/199755
Kind Code:
A1
Abstract:
Provided is a drug that has excellent effect of preventing and/or treating dementia. The drug comprises a carbostyril derivative represented by formula (1) [wherein: R represents a cycloalkyl group; A represents a lower alkyl group; and the bond between the 3- and 4-positions of the carbostyril nucleus is either a single bond or a double bond] and dihydroquercetin.
Inventors:
MATSUMOTO TADAMASA (JP)
IHARA MASAFUMI (JP)
SAITO SATOSHI (JP)
FUKUSHIMA MASANORI (JP)
IHARA MASAFUMI (JP)
SAITO SATOSHI (JP)
FUKUSHIMA MASANORI (JP)
Application Number:
PCT/JP2017/017195
Publication Date:
November 23, 2017
Filing Date:
May 01, 2017
Export Citation:
Assignee:
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
MATSUMOTO TADAMASA (JP)
FOUNDATION FOR BIOMEDICAL RES AND INNOVATION (JP)
MATSUMOTO TADAMASA (JP)
FOUNDATION FOR BIOMEDICAL RES AND INNOVATION (JP)
International Classes:
A61K31/4709; A61K31/353; A61P25/14; A61P25/16; A61P25/28
Domestic Patent References:
| WO2013187075A1 | 2013-12-19 | |||
| WO2009153009A1 | 2009-12-23 |
Foreign References:
| JP2006518732A | 2006-08-17 |
Other References:
PARK S. H. ET AL.: "Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid beta-induced cognitive deficits associated with decreased amyloid beta accumulation", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 408, 2011, pages 602 - 608, XP028214564, Retrieved from the Internet
HIRAMATSU MASAYUKI ET AL.: "Cilostazol prevents amyloid beta peptide25-35-induced memory impairment and oxidative stress in mice", BRITISH JOURNAL OF PHARMACOLOGY, vol. 161, 2010, pages 1899 - 1912, XP002474921, Retrieved from the Internet
SATO MIZUHO ET AL.: "Site-specific Inhibitory Mechanism for Amyloid beta42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 32, 2013, pages 23212 - 23224, XP002474921, Retrieved from the Internet
KIM YU RI ET AL.: "Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke", PSYCHOPHARMACOLOGY, vol. 233, March 2016 (2016-03-01), pages 1055 - 1066, XP035629786
YONEYAMA MASANORI ET AL.: "Beneficial Effect of Cilostazol-Mediated Neuronal Repair Following Trimethyltin-Induced Neuronal Loss in the Dentate Gyrus", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 93, 19 August 2014 (2014-08-19), pages 56 - 66, XP002474925
AGRAWAL ROHIT ET AL.: "Antidepressant Activity of Cilostazol: An Experimental Study", WORLD JOURNAL OF PHARMACEUTICAL RESEARCH, vol. 4, no. 2, 2015, pages 833 - 841, XP002474931
PARK SO YOUN ET AL.: "Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of beta- Amyloid Accumulation and Neurotoxicity via the Supression of P-JAK2/P-STAT3/NF-kB/BACE1 Signaling Pathways", PLOS ONE, vol. 11, no. 12, 15 December 2016 (2016-12-15), pages 1 - 17, XP002474932, Retrieved from the Internet
See also references of EP 3459545A4
HIRAMATSU MASAYUKI ET AL.: "Cilostazol prevents amyloid beta peptide25-35-induced memory impairment and oxidative stress in mice", BRITISH JOURNAL OF PHARMACOLOGY, vol. 161, 2010, pages 1899 - 1912, XP002474921, Retrieved from the Internet
SATO MIZUHO ET AL.: "Site-specific Inhibitory Mechanism for Amyloid beta42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 32, 2013, pages 23212 - 23224, XP002474921, Retrieved from the Internet
KIM YU RI ET AL.: "Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke", PSYCHOPHARMACOLOGY, vol. 233, March 2016 (2016-03-01), pages 1055 - 1066, XP035629786
YONEYAMA MASANORI ET AL.: "Beneficial Effect of Cilostazol-Mediated Neuronal Repair Following Trimethyltin-Induced Neuronal Loss in the Dentate Gyrus", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 93, 19 August 2014 (2014-08-19), pages 56 - 66, XP002474925
AGRAWAL ROHIT ET AL.: "Antidepressant Activity of Cilostazol: An Experimental Study", WORLD JOURNAL OF PHARMACEUTICAL RESEARCH, vol. 4, no. 2, 2015, pages 833 - 841, XP002474931
PARK SO YOUN ET AL.: "Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of beta- Amyloid Accumulation and Neurotoxicity via the Supression of P-JAK2/P-STAT3/NF-kB/BACE1 Signaling Pathways", PLOS ONE, vol. 11, no. 12, 15 December 2016 (2016-12-15), pages 1 - 17, XP002474932, Retrieved from the Internet
See also references of EP 3459545A4
Attorney, Agent or Firm:
MAEDA & PARTNERS (JP)
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