DRUG-RELEASE CONTROLLING SYSTEM

WIPO Patent Application WO/2002/015888

A1

A system of controlling drug-release which makes it possible to appropriately control the release speed and prolongation time of a drug and can be applied to retina or the vitreous body without any restriction in drug type. By using this drug-release controlling system which comprises nanospheres composed of fine particles made of a nano-sized synthetic biodegradable polymer and a drug uniformly contained therein, the drug can be efficiently delivered to the retina or the vitreous body, i.e., the target site. It is preferable that the above-described synthetic biodegradable polymer is polylactic acid or a lactic acid/glycolic acid copolymer. It is preferable that the drug is contained in the fine particles as a matrix. The average particle size of the nanospheres preferably ranges from 50 to 200 nm.

OGURA YUICHIRO (JP)
KUNOU NORIYUKI (JP)

PCT/JP2001/007290

February 28, 2002

August 24, 2001

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SANTEN PHARMACEUTICAL CO LTD (JP)
OGURA YUICHIRO (JP)
KUNOU NORIYUKI (JP)

A61K9/00; A61K9/51; A61P27/02; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P37/06; (IPC1-7): A61K9/51; A61K9/00; A61K47/34; A61K45/00; A61P27/02; A61P29/00; A61P37/06; A61P31/12; A61P31/04; A61P31/10

US5308624A	1994-05-03
JPH04208217A	1992-07-29
JPH0558882A	1993-03-09
EP0330180A1	1989-08-30

T. NIWA ET AL.: "Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with D,L-lactide/glycolode copolymer by a novel spontaneous emulsification solvent duffusion method and the drug release behavior", JOURNAL OF CONTROLLED RELEASE, vol. 25, 1993, pages 89 - 98, XP002949590

Kishimoto, Einosuke c/o KISHIMOTO & CO. Inaba Building (3rd Floor 13-18, Nishishinsaibashi 1-chom, Chuo-ku Osaka-shi Osaka, JP)

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