DRUG-SUSTAINED RELEASE CARRIER

WIPO Patent Application WO/2004/050712

A1

It is intended to provide a completely biodegradable and highly safe sustained release preparation of a protein or a peptide in which the protein or the peptide can be enclosed at a high enclosure ratio without inhibiting its biological activity. Namely, a process for producing a hyaluronic acid derivative gel characterized by comprising crosslinking and hydrogelling a hyaluronic acid derivative, which has hydrazide introduced into hyaluronic acid (HA), in a solution of pH 6 or below in the coexistence of a protein or a peptide. Thus, the protein or the peptide can be efficiently enclosed in the hydrogel and sustainedly released therefrom while maintaining its biological activity.

SHIMOBOJI TSUYOSHI (JP)
MOTOKAWA KEIKO (JP)
NAKAMURA TERUO (JP)

PCT/JP2003/015259

June 17, 2004

November 28, 2003

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CHUGAI PHARMACEUTICAL CO LTD (JP)
SHIMOBOJI TSUYOSHI (JP)
MOTOKAWA KEIKO (JP)
NAKAMURA TERUO (JP)

A61K47/36; C08B37/08; (IPC1-7): C08B37/08; A61K47/36

WO1995015168A1	1995-06-08
WO2002006373A1	2002-01-24
WO1999011703A1	1999-03-11

PRESTWICH ET AL.: "Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives", JOURNAL OF CONTROLLED RELEASE, vol. 53, no. 1-3, 1998, pages 93 - 103, XP004121260
VERCRUYSSE ET AL.: "Synthesis and in Vitro Degradation of New Polyvalent hydrazide Cross-Linked Hydrogels of Hyaluronic Acid", BIOCONJUGATE CHEM., vol. 8, no. 5, 1997, pages 686 - 694, XP002977286

Shamoto, Ichio (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo, JP)

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